null
SMILES: Cn1cnnc1C[C@@]1(C[C@@H](C1)C#N)c1cccc(c1)N1Cc2c(cc(CNC3CC4C(C3)C4(F)F)cc2C(F)(F)F)C1=O
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427] (Homo sapiens (Human)) | BDBM585797 (US11530229, Compound 12) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The ability of candidate compounds to displace a known inhibitor and thereby inhibit Cbl-b activity was measured by monitoring the interaction of Cbl... | Citation and Details BindingDB Entry DOI: 10.7270/Q2280CGT | |||||||||||
More data for this Ligand-Target Pair |