null

SMILES: COc1ccc(C[C@@H]2NC(=O)[C@@H]3CC\C=C/CO[C@H]4C[C@H](N(C4)C(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC(=O)[C@@H](C)NC(=O)[C@H](CCCCN)NC(=O)CCSCc4cccc(CSC[C@H](NC(=O)[C@]5(C)CCCN5C2=O)C(N)=O)c4)C(=O)N3)cc1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 586338   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor (Homo sapiens (Human))	BDBM586338 (US11530244, Compound 509) Show SMILES COc1ccc(C[C@@H]2NC(=O)[C@@H]3CC\C=C/CO[C@H]4C[C@H](N(C4)C(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC(=O)[C@@H](C)NC(=O)[C@H](CCCCN)NC(=O)CCSCc4cccc(CSC[C@H](NC(=O)[C@]5(C)CCCN5C2=O)C(N)=O)c4)C(=O)N3)cc1 |r,c:14| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...				Citation and Details BindingDB Entry DOI: 10.7270/Q2SQ9476
					More data for this Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor (Homo sapiens (Human))	BDBM586338 (US11530244, Compound 509) Show SMILES COc1ccc(C[C@@H]2NC(=O)[C@@H]3CC\C=C/CO[C@H]4C[C@H](N(C4)C(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC(=O)[C@@H](C)NC(=O)[C@H](CCCCN)NC(=O)CCSCc4cccc(CSC[C@H](NC(=O)[C@]5(C)CCCN5C2=O)C(N)=O)c4)C(=O)N3)cc1 |r,c:14| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2SQ9476
					More data for this Ligand-Target Pair