BindingDB PrimarySearch

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SMILES: Cn1cc(cn1)-c1ccc2ncc(-c3cccc(N[C@H]4CNC[C@@H]4F)n3)n2c1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 621166
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM621166 (N-((3S,4S)-4-fluoro- pyrrolidin-3-yl)-6-(6-(1- met...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	0.0800	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835H] (Homo sapiens (Human))	BDBM621166 (N-((3S,4S)-4-fluoro- pyrrolidin-3-yl)-6-(6-(1- met...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835V] (Homo sapiens (Human))	BDBM621166 (N-((3S,4S)-4-fluoro- pyrrolidin-3-yl)-6-(6-(1- met...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (D835Y) (Homo sapiens (Human))	BDBM621166 (N-((3S,4S)-4-fluoro- pyrrolidin-3-yl)-6-(6-(1- met...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	0.240	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM621166 (N-((3S,4S)-4-fluoro- pyrrolidin-3-yl)-6-(6-(1- met...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [572-603] (Homo sapiens (Human))	BDBM621166 (N-((3S,4S)-4-fluoro- pyrrolidin-3-yl)-6-(6-(1- met...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3 [F691L] (Homo sapiens (Human))	BDBM621166 (N-((3S,4S)-4-fluoro- pyrrolidin-3-yl)-6-(6-(1- met...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [K663Q] (Homo sapiens (Human))	BDBM621166 (N-((3S,4S)-4-fluoro- pyrrolidin-3-yl)-6-(6-(1- met...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [N841I] (Homo sapiens (Human))	BDBM621166 (N-((3S,4S)-4-fluoro- pyrrolidin-3-yl)-6-(6-(1- met...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	0.470	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [R834Q] (Homo sapiens (Human))	BDBM621166 (N-((3S,4S)-4-fluoro- pyrrolidin-3-yl)-6-(6-(1- met...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3 [D835V] (Homo sapiens (Human))	BDBM621166 (N-((3S,4S)-4-fluoro- pyrrolidin-3-yl)-6-(6-(1- met...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	0.0120	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair