Found 16 hits for monomerid = 625351 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625351
(US20230322769, Compound 64 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 1.17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM625351
(US20230322769, Compound 64 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 754 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [M918T]
(Homo sapiens (Human)) | BDBM625351
(US20230322769, Compound 64 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 1.62 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Coiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625351
(US20230322769, Compound 64 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 1.02 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM625351
(US20230322769, Compound 64 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 23.9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM625351
(US20230322769, Compound 64 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 4.74E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625351
(US20230322769, Compound 64 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 26.6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [V804M]
(Homo sapiens (Human)) | BDBM625351
(US20230322769, Compound 64 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 111 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [M918T]
(Homo sapiens (Human)) | BDBM625351
(US20230322769, Compound 64 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 42.8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Coiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625351
(US20230322769, Compound 64 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 30.7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM625351
(US20230322769, Compound 64 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 387 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625351
(US20230322769, Compound 64 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 18.6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [V804M]
(Homo sapiens (Human)) | BDBM625351
(US20230322769, Compound 64 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 38.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [M918T]
(Homo sapiens (Human)) | BDBM625351
(US20230322769, Compound 64 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 22.3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Coiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625351
(US20230322769, Compound 64 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [V804M]
(Homo sapiens (Human)) | BDBM625351
(US20230322769, Compound 64 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 1.01 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |