BDBM6397 2-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridin-3-yl)amino]ethan-1-ol::2-{5-[6-(3-Chloro-phenylamino)-pyrazin-2-yl]-pyridin-3-ylamino}-ethanol::Pyrazine-Pyridine Biheteroaryl 38

SMILES: OCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1

InChI Key: InChIKey=NDENTZARMCMWHO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 6397   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
VEGFR-2 (KDR) (Rattus norvegicus (rat))	BDBM6397 (2-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...) Show SMILES OCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1 Show InChI InChI=1S/C17H16ClN5O/c18-13-2-1-3-14(7-13)22-17-11-20-10-16(23-17)12-6-15(9-19-8-12)21-4-5-24/h1-3,6-11,21,24H,4-5H2,(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	275	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...				J Med Chem 48: 4892-909 (2005) Article DOI: 10.1021/jm058205b BindingDB Entry DOI: 10.7270/Q2NC5ZD5
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1) (Homo sapiens (Human))	BDBM6397 (2-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...) Show SMILES OCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1 Show InChI InChI=1S/C17H16ClN5O/c18-13-2-1-3-14(7-13)22-17-11-20-10-16(23-17)12-6-15(9-19-8-12)21-4-5-24/h1-3,6-11,21,24H,4-5H2,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...				J Med Chem 48: 4892-909 (2005) Article DOI: 10.1021/jm058205b BindingDB Entry DOI: 10.7270/Q2NC5ZD5
					More data for this Ligand-Target Pair