BDBM6420 N-(3-Chlorophenyl)-6-[5-[[3-(1H-pyrazol-1-yl)propyl]-amino]-3-pyridinyl]-2-pyrazinamine::N-(3-chlorophenyl)-6-(5-{[3-(1H-pyrazol-1-yl)propyl]amino}pyridin-3-yl)pyrazin-2-amine::Pyrazine-Pyridine Biheteroaryl 57

SMILES: Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCn3cccn3)c2)c1

InChI Key: InChIKey=YHWHYCTUDCULTF-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 6420   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-Dependent Kinase 1 (CDK1) (Homo sapiens (Human))	BDBM6420 (N-(3-Chlorophenyl)-6-[5-[[3-(1H-pyrazol-1-yl)propy...) Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCn3cccn3)c2)c1 Show InChI InChI=1S/C21H20ClN7/c22-17-4-1-5-18(11-17)27-21-15-24-14-20(28-21)16-10-19(13-23-12-16)25-6-2-8-29-9-3-7-26-29/h1,3-5,7,9-15,25H,2,6,8H2,(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...				J Med Chem 48: 4892-909 (2005) Article DOI: 10.1021/jm058205b BindingDB Entry DOI: 10.7270/Q2NC5ZD5
					More data for this Ligand-Target Pair
VEGFR-2 (KDR) (Rattus norvegicus (rat))	BDBM6420 (N-(3-Chlorophenyl)-6-[5-[[3-(1H-pyrazol-1-yl)propy...) Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCn3cccn3)c2)c1 Show InChI InChI=1S/C21H20ClN7/c22-17-4-1-5-18(11-17)27-21-15-24-14-20(28-21)16-10-19(13-23-12-16)25-6-2-8-29-9-3-7-26-29/h1,3-5,7,9-15,25H,2,6,8H2,(H,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...				J Med Chem 48: 4892-909 (2005) Article DOI: 10.1021/jm058205b BindingDB Entry DOI: 10.7270/Q2NC5ZD5
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM6420 (N-(3-Chlorophenyl)-6-[5-[[3-(1H-pyrazol-1-yl)propy...) Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCn3cccn3)c2)c1 Show InChI InChI=1S/C21H20ClN7/c22-17-4-1-5-18(11-17)27-21-15-24-14-20(28-21)16-10-19(13-23-12-16)25-6-2-8-29-9-3-7-26-29/h1,3-5,7,9-15,25H,2,6,8H2,(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	326	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...				J Med Chem 48: 4892-909 (2005) Article DOI: 10.1021/jm058205b BindingDB Entry DOI: 10.7270/Q2NC5ZD5
					More data for this Ligand-Target Pair
Glycogen Synthase Kinase-3, beta (Oryctolagus cuniculus (rabbit))	BDBM6420 (N-(3-Chlorophenyl)-6-[5-[[3-(1H-pyrazol-1-yl)propy...) Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCn3cccn3)c2)c1 Show InChI InChI=1S/C21H20ClN7/c22-17-4-1-5-18(11-17)27-21-15-24-14-20(28-21)16-10-19(13-23-12-16)25-6-2-8-29-9-3-7-26-29/h1,3-5,7,9-15,25H,2,6,8H2,(H,27,28)	GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	606	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...				J Med Chem 48: 4892-909 (2005) Article DOI: 10.1021/jm058205b BindingDB Entry DOI: 10.7270/Q2NC5ZD5
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM6420 (N-(3-Chlorophenyl)-6-[5-[[3-(1H-pyrazol-1-yl)propy...) Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCn3cccn3)c2)c1 Show InChI InChI=1S/C21H20ClN7/c22-17-4-1-5-18(11-17)27-21-15-24-14-20(28-21)16-10-19(13-23-12-16)25-6-2-8-29-9-3-7-26-29/h1,3-5,7,9-15,25H,2,6,8H2,(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...				J Med Chem 48: 4892-909 (2005) Article DOI: 10.1021/jm058205b BindingDB Entry DOI: 10.7270/Q2NC5ZD5
					More data for this Ligand-Target Pair