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BDBM65532 (S)-N-(6-(hydroxyamino)-6-oxohexyl)-4-(3-(2-oxo-1-phenyl-2-(p-tolylamino)ethyl)ureido)benzamide (L9)

SMILES: Cc1ccc(NC(=O)[C@@H](NC(=O)Nc2ccc(cc2)C(=O)NCCCCCC(=O)NO)c2ccccc2)cc1

InChI Key: InChIKey=QGTRPJWPZHJGEC-SANMLTNESA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 65532   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone deacetylase 8


(Homo sapiens (Human))		BDBM65532
PNG
((S)-N-(6-(hydroxyamino)-6-oxohexyl)-4-(3-(2-oxo-1-...)
Show SMILES Cc1ccc(NC(=O)[C@@H](NC(=O)Nc2ccc(cc2)C(=O)NCCCCCC(=O)NO)c2ccccc2)cc1
Show InChI InChI=1S/C29H33N5O5/c1-20-11-15-23(16-12-20)31-28(37)26(21-8-4-2-5-9-21)33-29(38)32-24-17-13-22(14-18-24)27(36)30-19-7-3-6-10-25(35)34-39/h2,4-5,8-9,11-18,26,39H,3,6-7,10,19H2,1H3,(H,30,36)(H,31,37)(H,34,35)(H2,32,33,38)/t26-/m0/s1
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Article
PubMed
n/an/a 1.87E+3n/an/an/an/an/an/a



Qingdao University



Assay Description
The nucleus extract was extracted from HDAC8 enzyme was expressed in Escherichia coli. Boc-Lys (acetyl)-AMC was used as the substrate of HDAC. SAHA w...

J Enzyme Inhib Med Chem 29: 582-9 (2014)


Article DOI: 10.3109/14756366.2013.827678
BindingDB Entry DOI: 10.7270/Q2S46Q3F
More data for this
Ligand-Target Pair