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BDBM65534 (S)-N-(6-(hydroxyamino)-6-oxohexyl)-4-(3-(2-((2-methoxyphenyl)amino)-2-oxo-1-phenylethyl)ureido)benzamide (L10)

SMILES: COc1ccccc1NC(=O)[C@@H](NC(=O)Nc1ccc(cc1)C(=O)NCCCCCC(=O)NO)c1ccccc1

InChI Key: InChIKey=VQNYTQMQQKXHFV-SANMLTNESA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 65534   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone deacetylase 8


(Homo sapiens (Human))		BDBM65534
PNG
((S)-N-(6-(hydroxyamino)-6-oxohexyl)-4-(3-(2-((2-me...)
Show SMILES COc1ccccc1NC(=O)[C@@H](NC(=O)Nc1ccc(cc1)C(=O)NCCCCCC(=O)NO)c1ccccc1
Show InChI InChI=1S/C29H33N5O6/c1-40-24-13-8-7-12-23(24)32-28(37)26(20-10-4-2-5-11-20)33-29(38)31-22-17-15-21(16-18-22)27(36)30-19-9-3-6-14-25(35)34-39/h2,4-5,7-8,10-13,15-18,26,39H,3,6,9,14,19H2,1H3,(H,30,36)(H,32,37)(H,34,35)(H2,31,33,38)/t26-/m0/s1
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MMDB

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Similars
Article
PubMed
n/an/a 1.77E+3n/an/an/an/an/an/a



Qingdao University



Assay Description
The nucleus extract was extracted from HDAC8 enzyme was expressed in Escherichia coli. Boc-Lys (acetyl)-AMC was used as the substrate of HDAC. SAHA w...

J Enzyme Inhib Med Chem 29: 582-9 (2014)


Article DOI: 10.3109/14756366.2013.827678
BindingDB Entry DOI: 10.7270/Q2S46Q3F
More data for this
Ligand-Target Pair