BDBM65547 phenylglycine containing lead compound (4h)

SMILES: CC(C)(C)OC(=O)NC(C(=O)Nc1ccc(cc1)C(=O)NO)c1ccccc1

InChI Key: InChIKey=HZCLSSBYCNNVNM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 65547   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 8 (Homo sapiens (Human))	BDBM65547 (phenylglycine containing lead compound (4h)) Show SMILES CC(C)(C)OC(=O)NC(C(=O)Nc1ccc(cc1)C(=O)NO)c1ccccc1 Show InChI InChI=1S/C20H23N3O5/c1-20(2,3)28-19(26)22-16(13-7-5-4-6-8-13)18(25)21-15-11-9-14(10-12-15)17(24)23-27/h4-12,16,27H,1-3H3,(H,21,25)(H,22,26)(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.52E+3	n/a	n/a	n/a	n/a	n/a	n/a
Qingdao University					Assay Description The nucleus extract was extracted from HDAC8 enzyme was expressed in Escherichia coli. Boc-Lys (acetyl)-AMC was used as the substrate of HDAC. SAHA w...				J Enzyme Inhib Med Chem 29: 582-9 (2014) Article DOI: 10.3109/14756366.2013.827678 BindingDB Entry DOI: 10.7270/Q2S46Q3F
					More data for this Ligand-Target Pair