BDBM6954 3,11-diazatetracyclo[8.7.0.0^{2,7}.0^{12,17}]heptadeca-1,3,5,7,9,12,14,16-octaene::carbazole deriv. 14

SMILES: c1ccc2c(c1)[nH]c1ccc3cccnc3c21

InChI Key: InChIKey=MZXDPTWGJXNUMW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 6954   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human))	BDBM6954 (3,11-diazatetracyclo[8.7.0.0^{2,7}.0^{12,17}]hepta...) Show SMILES c1ccc2c(c1)[nH]c1ccc3cccnc3c21 Show InChI InChI=1S/C15H10N2/c1-2-6-12-11(5-1)14-13(17-12)8-7-10-4-3-9-16-15(10)14/h1-9,17H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.42E+5	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
					More data for this Ligand-Target Pair