BDBM7319 6-Oxo-5,6,7,12-tetrahydro-indolo[3,2-d][1]benzazepine-2-carbonitrile::9-oxo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octadeca-1(11),2,4,6,12(17),13,15-heptaene-4-carbonitrile::NSC 708243::Paullone Analogue 54

SMILES: O=C1Cc2c([nH]c3ccccc23)-c2cc(ccc2N1)C#N

InChI Key: InChIKey=UQYAOCPYYWTPID-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 7319   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-Dependent Kinase 1 (CDK1) (Marthasterias glacialis (starfish))	BDBM7319 (6-Oxo-5,6,7,12-tetrahydro-indolo[3,2-d][1]benzazep...) Show SMILES O=C1Cc2c([nH]c3ccccc23)-c2cc(ccc2N1)C#N Show InChI InChI=1S/C17H11N3O/c18-9-10-5-6-15-13(7-10)17-12(8-16(21)19-15)11-3-1-2-4-14(11)20-17/h1-7,20H,8H2,(H,19,21)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	7.2	30
Universitat Hamburg					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 47: 22-36 (2004) Article DOI: 10.1021/jm0308904 BindingDB Entry DOI: 10.7270/Q28050TR
					More data for this Ligand-Target Pair
Glycogen Synthase Kinase-3, beta (Rattus norvegicus (rat))	BDBM7319 (6-Oxo-5,6,7,12-tetrahydro-indolo[3,2-d][1]benzazep...) Show SMILES O=C1Cc2c([nH]c3ccccc23)-c2cc(ccc2N1)C#N Show InChI InChI=1S/C17H11N3O/c18-9-10-5-6-15-13(7-10)17-12(8-16(21)19-15)11-3-1-2-4-14(11)20-17/h1-7,20H,8H2,(H,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	30
Universitat Hamburg					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 47: 22-36 (2004) Article DOI: 10.1021/jm0308904 BindingDB Entry DOI: 10.7270/Q28050TR
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5) (Homo sapiens (Human))	BDBM7319 (6-Oxo-5,6,7,12-tetrahydro-indolo[3,2-d][1]benzazep...) Show SMILES O=C1Cc2c([nH]c3ccccc23)-c2cc(ccc2N1)C#N Show InChI InChI=1S/C17H11N3O/c18-9-10-5-6-15-13(7-10)17-12(8-16(21)19-15)11-3-1-2-4-14(11)20-17/h1-7,20H,8H2,(H,19,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.50E+5	n/a	n/a	n/a	n/a	n/a	30
Universitat Hamburg					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 47: 22-36 (2004) Article DOI: 10.1021/jm0308904 BindingDB Entry DOI: 10.7270/Q28050TR
					More data for this Ligand-Target Pair