BDBM7337 13-methyl-3-thia-7,17-diazatetracyclo[8.7.0.0^{2,6}.0^{11,16}]heptadeca-1(10),2(6),4,11(16),12,14-hexaen-8-one::8-Methyl-6,11-dihydro-thieno[3 ,2 :2,3]azepino[4,5-b]indol-5(4H)-one::NSC 709124::Paullone Analogue 72

SMILES: Cc1ccc2[nH]c-3c(CC(=O)Nc4ccsc-34)c2c1

InChI Key: InChIKey=IGVYXSVOVAENJU-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 7337   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B (Marthasterias glacialis (starfish))	BDBM7337 (13-methyl-3-thia-7,17-diazatetracyclo[8.7.0.0^{2,6...) Show SMILES Cc1ccc2[nH]c-3c(CC(=O)Nc4ccsc-34)c2c1 Show InChI InChI=1S/C15H12N2OS/c1-8-2-3-11-9(6-8)10-7-13(18)16-12-4-5-19-15(12)14(10)17-11/h2-6,17H,7H2,1H3,(H,16,18)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	30
Universitat Hamburg					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 47: 22-36 (2004) Article DOI: 10.1021/jm0308904 BindingDB Entry DOI: 10.7270/Q28050TR
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Rattus norvegicus (rat))	BDBM7337 (13-methyl-3-thia-7,17-diazatetracyclo[8.7.0.0^{2,6...) Show SMILES Cc1ccc2[nH]c-3c(CC(=O)Nc4ccsc-34)c2c1 Show InChI InChI=1S/C15H12N2OS/c1-8-2-3-11-9(6-8)10-7-13(18)16-12-4-5-19-15(12)14(10)17-11/h2-6,17H,7H2,1H3,(H,16,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	30
Universitat Hamburg					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 47: 22-36 (2004) Article DOI: 10.1021/jm0308904 BindingDB Entry DOI: 10.7270/Q28050TR
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM7337 (13-methyl-3-thia-7,17-diazatetracyclo[8.7.0.0^{2,6...) Show SMILES Cc1ccc2[nH]c-3c(CC(=O)Nc4ccsc-34)c2c1 Show InChI InChI=1S/C15H12N2OS/c1-8-2-3-11-9(6-8)10-7-13(18)16-12-4-5-19-15(12)14(10)17-11/h2-6,17H,7H2,1H3,(H,16,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	30
Universitat Hamburg					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 47: 22-36 (2004) Article DOI: 10.1021/jm0308904 BindingDB Entry DOI: 10.7270/Q28050TR
					More data for this Ligand-Target Pair