BDBM7347 4-{5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol::6-phenyl[5H]pyrrolo[2,3-b]pyrazine (aloisine) 15

SMILES: Oc1ccc(cc1)-c1cc2nccnc2[nH]1

InChI Key: InChIKey=JZGBONHLJLFZPT-UHFFFAOYSA-N

Data: 3 IC50

PDB links: 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 7347   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycogen Synthase Kinase-3, beta (Rattus norvegicus (rat))	BDBM7347 (4-{5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | 6-phenyl...) Show SMILES Oc1ccc(cc1)-c1cc2nccnc2[nH]1 Show InChI InChI=1S/C12H9N3O/c16-9-3-1-8(2-4-9)10-7-11-12(15-10)14-6-5-13-11/h1-7,16H,(H,14,15)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	30
Faculte de Medecine et de Pharmacie					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 46: 222-36 (2003) Article DOI: 10.1021/jm020319p BindingDB Entry DOI: 10.7270/Q2474820
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5) (Homo sapiens (Human))	BDBM7347 (4-{5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | 6-phenyl...) Show SMILES Oc1ccc(cc1)-c1cc2nccnc2[nH]1 Show InChI InChI=1S/C12H9N3O/c16-9-3-1-8(2-4-9)10-7-11-12(15-10)14-6-5-13-11/h1-7,16H,(H,14,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	30
Faculte de Medecine et de Pharmacie					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 46: 222-36 (2003) Article DOI: 10.1021/jm020319p BindingDB Entry DOI: 10.7270/Q2474820
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1) (Marthasterias glacialis (starfish))	BDBM7347 (4-{5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | 6-phenyl...) Show SMILES Oc1ccc(cc1)-c1cc2nccnc2[nH]1 Show InChI InChI=1S/C12H9N3O/c16-9-3-1-8(2-4-9)10-7-11-12(15-10)14-6-5-13-11/h1-7,16H,(H,14,15)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	7.2	30
Faculte de Medecine et de Pharmacie					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 46: 222-36 (2003) Article DOI: 10.1021/jm020319p BindingDB Entry DOI: 10.7270/Q2474820
					More data for this Ligand-Target Pair