BDBM7370 6-(4-chlorophenyl)-7-(propan-2-yl)-5H-pyrrolo[2,3-b]pyrazine::6-(4-chlorophenyl)-7-isopropyl-5H-pyrrolo[2,3-b]pyrazine::6-phenyl[5H]pyrrolo[2,3-b]pyrazine (aloisine) 37::Aloisine B

SMILES: CC(C)c1c([nH]c2nccnc12)-c1ccc(Cl)cc1

InChI Key: InChIKey=GFJIABMYYUGNEC-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 7370   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-Dependent Kinase 5 (CDK5) (Homo sapiens (Human))	BDBM7370 (6-(4-chlorophenyl)-7-(propan-2-yl)-5H-pyrrolo[2,3-...) Show SMILES CC(C)c1c([nH]c2nccnc12)-c1ccc(Cl)cc1 Show InChI InChI=1S/C15H14ClN3/c1-9(2)12-13(10-3-5-11(16)6-4-10)19-15-14(12)17-7-8-18-15/h3-9H,1-2H3,(H,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	30
Faculte de Medecine et de Pharmacie					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 46: 222-36 (2003) Article DOI: 10.1021/jm020319p BindingDB Entry DOI: 10.7270/Q2474820
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Rattus norvegicus (rat))	BDBM7370 (6-(4-chlorophenyl)-7-(propan-2-yl)-5H-pyrrolo[2,3-...) Show SMILES CC(C)c1c([nH]c2nccnc12)-c1ccc(Cl)cc1 Show InChI InChI=1S/C15H14ClN3/c1-9(2)12-13(10-3-5-11(16)6-4-10)19-15-14(12)17-7-8-18-15/h3-9H,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	30
Faculte de Medecine et de Pharmacie					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 46: 222-36 (2003) Article DOI: 10.1021/jm020319p BindingDB Entry DOI: 10.7270/Q2474820
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1) (Marthasterias glacialis (starfish))	BDBM7370 (6-(4-chlorophenyl)-7-(propan-2-yl)-5H-pyrrolo[2,3-...) Show SMILES CC(C)c1c([nH]c2nccnc12)-c1ccc(Cl)cc1 Show InChI InChI=1S/C15H14ClN3/c1-9(2)12-13(10-3-5-11(16)6-4-10)19-15-14(12)17-7-8-18-15/h3-9H,1-2H3,(H,18,19)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	850	n/a	n/a	n/a	n/a	7.2	30
Technische Universitat Braunschweig					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				Bioorg Med Chem Lett 14: 413-6 (2004) Article DOI: 10.1016/j.bmcl.2003.10.062 BindingDB Entry DOI: 10.7270/Q2BR8QDD
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM7370 (6-(4-chlorophenyl)-7-(propan-2-yl)-5H-pyrrolo[2,3-...) Show SMILES CC(C)c1c([nH]c2nccnc12)-c1ccc(Cl)cc1 Show InChI InChI=1S/C15H14ClN3/c1-9(2)12-13(10-3-5-11(16)6-4-10)19-15-14(12)17-7-8-18-15/h3-9H,1-2H3,(H,18,19)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	759	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang University Curated by ChEMBL					Assay Description Inhibitory concentration against Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 395-9 (2005) Article DOI: 10.1016/j.bmcl.2004.10.060 BindingDB Entry DOI: 10.7270/Q2WH2SR0
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Rattus norvegicus (rat))	BDBM7370 (6-(4-chlorophenyl)-7-(propan-2-yl)-5H-pyrrolo[2,3-...) Show SMILES CC(C)c1c([nH]c2nccnc12)-c1ccc(Cl)cc1 Show InChI InChI=1S/C15H14ClN3/c1-9(2)12-13(10-3-5-11(16)6-4-10)19-15-14(12)17-7-8-18-15/h3-9H,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	750	n/a	n/a	n/a	n/a	7.5	30
Technische Universitat Braunschweig					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				Bioorg Med Chem Lett 14: 413-6 (2004) Article DOI: 10.1016/j.bmcl.2003.10.062 BindingDB Entry DOI: 10.7270/Q2BR8QDD
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1) (Marthasterias glacialis (starfish))	BDBM7370 (6-(4-chlorophenyl)-7-(propan-2-yl)-5H-pyrrolo[2,3-...) Show SMILES CC(C)c1c([nH]c2nccnc12)-c1ccc(Cl)cc1 Show InChI InChI=1S/C15H14ClN3/c1-9(2)12-13(10-3-5-11(16)6-4-10)19-15-14(12)17-7-8-18-15/h3-9H,1-2H3,(H,18,19)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	850	n/a	n/a	n/a	n/a	n/a	30
Faculte de Medecine et de Pharmacie					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 46: 222-36 (2003) Article DOI: 10.1021/jm020319p BindingDB Entry DOI: 10.7270/Q2474820
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5) (Homo sapiens (Human))	BDBM7370 (6-(4-chlorophenyl)-7-(propan-2-yl)-5H-pyrrolo[2,3-...) Show SMILES CC(C)c1c([nH]c2nccnc12)-c1ccc(Cl)cc1 Show InChI InChI=1S/C15H14ClN3/c1-9(2)12-13(10-3-5-11(16)6-4-10)19-15-14(12)17-7-8-18-15/h3-9H,1-2H3,(H,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	7.2	30
Technische Universitat Braunschweig					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				Bioorg Med Chem Lett 14: 413-6 (2004) Article DOI: 10.1016/j.bmcl.2003.10.062 BindingDB Entry DOI: 10.7270/Q2BR8QDD
					More data for this Ligand-Target Pair