BDBM82123 Brinzolamide, BRZ

SMILES: CCN[C@@H]1CN(CCC(C)=O)S(=O)(=O)c2sc(cc12)S(N)(=O)=O

InChI Key: InChIKey=IGDJPTBULQZAQW-SNVBAGLBSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 82123   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Carbonic anhydrase 6 (CA-VI) (Homo sapiens (Human))	BDBM82123 (Brinzolamide, BRZ) Show SMILES CCN[C@@H]1CN(CCC(C)=O)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |r| Show InChI InChI=1S/C12H19N3O5S3/c1-3-14-10-7-15(5-4-8(2)16)23(19,20)12-9(10)6-11(21-12)22(13,17)18/h6,10,14H,3-5,7H2,1-2H3,(H2,13,17,18)/t10-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	0.900	-12.1	n/a	n/a	n/a	n/a	n/a	7.5	20
Institut des Biomolécules Max Mousseron (IBMM)					Assay Description Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...				Chem Biol Drug Des 74: 636-9 (2009) Article DOI: 10.1111/j.1747-0285.2009.00902.x BindingDB Entry DOI: 10.7270/Q2VX0F1H
					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM82123 (Brinzolamide, BRZ) Show SMILES CCN[C@@H]1CN(CCC(C)=O)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |r| Show InChI InChI=1S/C12H19N3O5S3/c1-3-14-10-7-15(5-4-8(2)16)23(19,20)12-9(10)6-11(21-12)22(13,17)18/h6,10,14H,3-5,7H2,1-2H3,(H2,13,17,18)/t10-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	3	-11.4	n/a	n/a	n/a	n/a	n/a	7.5	20
Institut des Biomolécules Max Mousseron (IBMM)					Assay Description Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...				Chem Biol Drug Des 74: 636-9 (2009) Article DOI: 10.1111/j.1747-0285.2009.00902.x BindingDB Entry DOI: 10.7270/Q2VX0F1H
					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM82123 (Brinzolamide, BRZ) Show SMILES CCN[C@@H]1CN(CCC(C)=O)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |r| Show InChI InChI=1S/C12H19N3O5S3/c1-3-14-10-7-15(5-4-8(2)16)23(19,20)12-9(10)6-11(21-12)22(13,17)18/h6,10,14H,3-5,7H2,1-2H3,(H2,13,17,18)/t10-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	4.50E+4	-5.83	n/a	n/a	n/a	n/a	n/a	7.5	20
Institut des Biomolécules Max Mousseron (IBMM)					Assay Description Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...				Chem Biol Drug Des 74: 636-9 (2009) Article DOI: 10.1111/j.1747-0285.2009.00902.x BindingDB Entry DOI: 10.7270/Q2VX0F1H
					More data for this Ligand-Target Pair