BDBM98014 US8486966, 8

SMILES: CCOc1cc(n[nH]1)-n1cnc2ccc(N[C@@H](CO)c3ccc(F)cn3)nc12

InChI Key: InChIKey=QORXXHJYKNVXNU-AWEZNQCLSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 98014   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM98014 (US8486966, 8) Show SMILES CCOc1cc(n[nH]1)-n1cnc2ccc(N[C@@H](CO)c3ccc(F)cn3)nc12 |r| Show InChI InChI=1S/C18H18FN7O2/c1-2-28-17-7-16(24-25-17)26-10-21-13-5-6-15(23-18(13)26)22-14(9-27)12-4-3-11(19)8-20-12/h3-8,10,14,27H,2,9H2,1H3,(H,22,23)(H,24,25)/t14-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	25
Astrazeneca AB US Patent					Assay Description JAK2 and Trk A kinase activity was determined by measuring the kinase's ability to phoshorylate synthetic tyrosine residues within a generic poly...				US Patent US8486966 (2013) BindingDB Entry DOI: 10.7270/Q26T0K7X
					More data for this Ligand-Target Pair