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BDBM98428 US8481733, 240

SMILES: Nc1nccn2c(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@H]1C[C@H](CO)C1

InChI Key: InChIKey=AHANKXNSVKLMQF-JCNLHEQBSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 98428   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))		BDBM98428
PNG
(US8481733, 240)
Show SMILES Nc1nccn2c(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@H]1C[C@H](CO)C1 |r,wU:23.26,wD:25.29,(-3.76,2.05,;-3.76,.51,;-5.09,-.26,;-5.09,-1.8,;-3.76,-2.57,;-2.43,-1.8,;-.96,-2.28,;-.06,-1.03,;-.96,.21,;-.56,1.7,;.92,2.1,;1.32,3.59,;.23,4.67,;.63,6.16,;2.12,6.56,;3.21,5.47,;4.7,5.87,;5.09,7.36,;4.01,8.45,;2.52,8.05,;-1.25,4.28,;-1.65,2.79,;-2.43,-.26,;-.56,-3.77,;.77,-4.54,;-0,-5.87,;.4,-7.36,;-.69,-8.45,;-1.33,-5.1,)|
Show InChI InChI=1S/C23H22N4O2/c24-22-21-20(16-6-8-19(9-7-16)29-18-4-2-1-3-5-18)26-23(27(21)11-10-25-22)17-12-15(13-17)14-28/h1-11,15,17,28H,12-14H2,(H2,24,25)/t15-,17-
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Similars
US Patent
n/an/a 139n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

US Patent


Assay Description
AlphaScreen (amplified luminescent proximity homogeneous assay) assay was used to test for ACK1 inhibitory activity.

US Patent US8481733 (2013)


BindingDB Entry DOI: 10.7270/Q2XD109J
More data for this
Ligand-Target Pair