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SMILES: Nc1cc(ccc1C(=O)c1ccccc1)-c1nc(C2CCC2)n2ccnc(N)c12

InChI Key: InChIKey=CXZKIBLOTGNXAP-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 98449   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Activated CDC42 kinase 1


(Homo sapiens (Human))		BDBM98449
PNG
(US8481733, 261)
Show SMILES Nc1cc(ccc1C(=O)c1ccccc1)-c1nc(C2CCC2)n2ccnc(N)c12
Show InChI InChI=1S/C23H21N5O/c24-18-13-16(9-10-17(18)21(29)14-5-2-1-3-6-14)19-20-22(25)26-11-12-28(20)23(27-19)15-7-4-8-15/h1-3,5-6,9-13,15H,4,7-8,24H2,(H2,25,26)
PDB
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KEGG

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Similars
US Patent
n/an/a 36.9n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

US Patent


Assay Description
AlphaScreen (amplified luminescent proximity homogeneous assay) assay was used to test for ACK1 inhibitory activity.

US Patent US8481733 (2013)


BindingDB Entry DOI: 10.7270/Q2XD109J
More data for this
Ligand-Target Pair