BDBM98553 US8492387, 122
SMILES: COc1ccc2c(CCC2(Cc2cc(ccc2OC)[N+]([O-])=O)c2cn(C)c(N)n2)c1
InChI Key: InChIKey=LOABEFJEEMGKBS-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-secretase 1 (Homo sapiens (Human)) | BDBM98553 (US8492387, 122) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | 6.5 | n/a |
Merck, Sharp & Dohme, Corp. US Patent | Assay Description End point electrochemiluminescence (ECL) assay: a homogeneous ECL assay is performed using a biotinylated BACE substrate. | US Patent US8492387 (2013) BindingDB Entry DOI: 10.7270/Q2DB80FN | |||||||||||
More data for this Ligand-Target Pair |