BDBM99010 US8497265, 466::US8497265, 470

SMILES: COc1ncccc1-c1cnc(nc1OC1CN(C1)c1ccc2ccccc2n1)N1CCC(CO)CC1

InChI Key: InChIKey=RLMWPIZMMMUVAL-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 99010   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase Type 10 (PDE10A) (Rattus norvegicus (rat))	BDBM99010 (US8497265, 466 | US8497265, 470) Show SMILES COc1ncccc1-c1cnc(nc1OC1CN(C1)c1ccc2ccccc2n1)N1CCC(CO)CC1 Show InChI InChI=1S/C28H30N6O3/c1-36-26-22(6-4-12-29-26)23-15-30-28(33-13-10-19(18-35)11-14-33)32-27(23)37-21-16-34(17-21)25-9-8-20-5-2-3-7-24(20)31-25/h2-9,12,15,19,21,35H,10-11,13-14,16-18H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).				US Patent US8497265 (2013) BindingDB Entry DOI: 10.7270/Q2VD6X39
					More data for this Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A) (Rattus norvegicus (rat))	BDBM99010 (US8497265, 466 | US8497265, 470) Show SMILES COc1ncccc1-c1cnc(nc1OC1CN(C1)c1ccc2ccccc2n1)N1CCC(CO)CC1 Show InChI InChI=1S/C28H30N6O3/c1-36-26-22(6-4-12-29-26)23-15-30-28(33-13-10-19(18-35)11-14-33)32-27(23)37-21-16-34(17-21)25-9-8-20-5-2-3-7-24(20)31-25/h2-9,12,15,19,21,35H,10-11,13-14,16-18H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).				US Patent US8497265 (2013) BindingDB Entry DOI: 10.7270/Q2VD6X39
					More data for this Ligand-Target Pair