BDBM99012 US8497265, 468

SMILES: OCC1CCN(CC1)c1ncc(C2=CCOCC2)c(OC2CN(C2)c2ccc3ccccc3n2)n1

InChI Key: InChIKey=GYPKGKLLWMFEDT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 99012   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase Type 10 (PDE10A) (Rattus norvegicus (rat))	BDBM99012 (US8497265, 468) Show SMILES OCC1CCN(CC1)c1ncc(C2=CCOCC2)c(OC2CN(C2)c2ccc3ccccc3n2)n1 |t:13| Show InChI InChI=1S/C27H31N5O3/c33-18-19-7-11-31(12-8-19)27-28-15-23(20-9-13-34-14-10-20)26(30-27)35-22-16-32(17-22)25-6-5-21-3-1-2-4-24(21)29-25/h1-6,9,15,19,22,33H,7-8,10-14,16-18H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).				US Patent US8497265 (2013) BindingDB Entry DOI: 10.7270/Q2VD6X39
					More data for this Ligand-Target Pair