BDBM99013 US8497265, 469

SMILES: CC(C)(C)OC(=O)N1CCC(=CC1)c1cnc(nc1OC1CN(C1)c1ccc2ccccc2n1)N1CCC(CO)CC1

InChI Key: InChIKey=IFSVPFWFNWGXOF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 99013   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase Type 10 (PDE10A) (Rattus norvegicus (rat))	BDBM99013 (US8497265, 469) Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1cnc(nc1OC1CN(C1)c1ccc2ccccc2n1)N1CCC(CO)CC1 |c:10| Show InChI InChI=1S/C32H40N6O4/c1-32(2,3)42-31(40)37-16-12-23(13-17-37)26-18-33-30(36-14-10-22(21-39)11-15-36)35-29(26)41-25-19-38(20-25)28-9-8-24-6-4-5-7-27(24)34-28/h4-9,12,18,22,25,39H,10-11,13-17,19-21H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).				US Patent US8497265 (2013) BindingDB Entry DOI: 10.7270/Q2VD6X39
					More data for this Ligand-Target Pair