BDBM99360 US8497281, 138::US9120769, 71::US9663470, 71
SMILES: Oc1c(Cl)cc(cc1Cl)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
InChI Key: InChIKey=PJDILBAYBUSUDB-PKHIMPSTSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM99360 (US8497281, 138 | US9120769, 71 | US9663470, 71) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 915 | n/a | n/a | n/a | n/a | 6.0 | 37 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international... | US Patent US8497281 (2013) BindingDB Entry DOI: 10.7270/Q2G44NXT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM99360 (US8497281, 138 | US9120769, 71 | US9663470, 71) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 915 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh US Patent | Assay Description In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio... | US Patent US9663470 (2017) BindingDB Entry DOI: 10.7270/Q2V40X8H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM99360 (US8497281, 138 | US9120769, 71 | US9663470, 71) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 915 | n/a | n/a | n/a | n/a | 6.0 | n/a |
Boehringer-Ingelheim International GmbH US Patent | Assay Description n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation... | US Patent US9120769 (2015) BindingDB Entry DOI: 10.7270/Q2XW4HK9 | |||||||||||
More data for this Ligand-Target Pair |