BDBM99438 US8497281, 216

SMILES: COc1ccc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4nc[nH]c4c3)c2c1

InChI Key: InChIKey=YUHSYHKOSQORFW-UZLBHIALSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 99438   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM99438 (US8497281, 216) Show SMILES COc1ccc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4nc[nH]c4c3)c2c1 |r| Show InChI InChI=1S/C21H21N3O2/c1-26-15-6-4-13-10-20-16(17(13)11-15)3-2-8-24(20)21(25)14-5-7-18-19(9-14)23-12-22-18/h4-7,9,11-12,16,20H,2-3,8,10H2,1H3,(H,22,23)/t16-,20+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	141	n/a	n/a	n/a	n/a	6.0	37
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...				US Patent US8497281 (2013) BindingDB Entry DOI: 10.7270/Q2G44NXT
					More data for this Ligand-Target Pair