BDBM99459 US8497281, 237

SMILES: Cc1nc2cc3C[C@H]4[C@H](CCCN4C(=O)c4ccc5nc[nH]c5c4)c3cc2o1

InChI Key: InChIKey=FGANXIQPUHEMEK-QRWLVFNGSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 99459   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM99459 (US8497281, 237) Show SMILES Cc1nc2cc3C[C@H]4[C@H](CCCN4C(=O)c4ccc5nc[nH]c5c4)c3cc2o1 |r| Show InChI InChI=1S/C22H20N4O2/c1-12-25-19-8-14-9-20-15(16(14)10-21(19)28-12)3-2-6-26(20)22(27)13-4-5-17-18(7-13)24-11-23-17/h4-5,7-8,10-11,15,20H,2-3,6,9H2,1H3,(H,23,24)/t15-,20+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	248	n/a	n/a	n/a	n/a	6.0	37
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...				US Patent US8497281 (2013) BindingDB Entry DOI: 10.7270/Q2G44NXT
					More data for this Ligand-Target Pair