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SMILES: O=C(N1CCC[C@H]2[C@@H]1Cc1cc3ncoc3cc21)c1ccc2nc[nH]c2c1

InChI Key: InChIKey=ORHZZVDQAPIJGK-KUHUBIRLSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 99460   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM99460
PNG
(US8497281, 238)
Show SMILES O=C(N1CCC[C@H]2[C@@H]1Cc1cc3ncoc3cc21)c1ccc2nc[nH]c2c1 |r|
Show InChI InChI=1S/C21H18N4O2/c26-21(12-3-4-16-17(6-12)23-10-22-16)25-5-1-2-14-15-9-20-18(24-11-27-20)7-13(15)8-19(14)25/h3-4,6-7,9-11,14,19H,1-2,5,8H2,(H,22,23)/t14-,19+/m1/s1
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Similars
US Patent
n/an/a 218n/an/an/an/a6.037



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...

US Patent US8497281 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NXT
More data for this
Ligand-Target Pair