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SMILES: OC(CN1C[C@H]2CCN(C(=O)[C@H]2C1)c1ccc(OCC(F)(F)F)cc1)c1ccc(Cl)cc1Cl

InChI Key: InChIKey=TZYWCWPNWKEQCG-ANEWXZNUSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 99498   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hormone-sensitive lipase


(Homo sapiens (Human))		BDBM99498
PNG
(US8501768, 26)
Show SMILES OC(CN1C[C@H]2CCN(C(=O)[C@H]2C1)c1ccc(OCC(F)(F)F)cc1)c1ccc(Cl)cc1Cl |r|
Show InChI InChI=1S/C23H23Cl2F3N2O3/c24-15-1-6-18(20(25)9-15)21(31)12-29-10-14-7-8-30(22(32)19(14)11-29)16-2-4-17(5-3-16)33-13-23(26,27)28/h1-6,9,14,19,21,31H,7-8,10-13H2/t14-,19+,21?/m1/s1
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PC cid
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US Patent
n/an/a 33n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HSL enzyme activity was measured by a colorimetric assay.

US Patent US8501768 (2013)


BindingDB Entry DOI: 10.7270/Q26Q1VW3
More data for this
Ligand-Target Pair