BDBM99514 US8501936, 10

SMILES: CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3ccc(OCCN4CCCC4)cc3)nc12

InChI Key: InChIKey=UAIRELYYNQRVKN-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 99514   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM99514 (US8501936, 10) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3ccc(OCCN4CCCC4)cc3)nc12 Show InChI InChI=1S/C25H27N5O3S/c1-34(31,32)22-12-6-19(7-13-22)23-5-4-16-30-24(23)27-25(28-30)26-20-8-10-21(11-9-20)33-18-17-29-14-2-3-15-29/h4-13,16H,2-3,14-15,17-18H2,1H3,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	206	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. US Patent					Assay Description The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...				US Patent US8501936 (2013) BindingDB Entry DOI: 10.7270/Q22Z1455
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM99514 (US8501936, 10) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3ccc(OCCN4CCCC4)cc3)nc12 Show InChI InChI=1S/C25H27N5O3S/c1-34(31,32)22-12-6-19(7-13-22)23-5-4-16-30-24(23)27-25(28-30)26-20-8-10-21(11-9-20)33-18-17-29-14-2-3-15-29/h4-13,16H,2-3,14-15,17-18H2,1H3,(H,26,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	40.3	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. US Patent					Assay Description The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...				US Patent US8501936 (2013) BindingDB Entry DOI: 10.7270/Q22Z1455
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM99514 (US8501936, 10) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3ccc(OCCN4CCCC4)cc3)nc12 Show InChI InChI=1S/C25H27N5O3S/c1-34(31,32)22-12-6-19(7-13-22)23-5-4-16-30-24(23)27-25(28-30)26-20-8-10-21(11-9-20)33-18-17-29-14-2-3-15-29/h4-13,16H,2-3,14-15,17-18H2,1H3,(H,26,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. US Patent					Assay Description The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...				US Patent US8501936 (2013) BindingDB Entry DOI: 10.7270/Q22Z1455
					More data for this Ligand-Target Pair