BDBM99683 US8501936, 184

SMILES: CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3cccc(c3)C3CCN(CC(N)=O)CC3)nc12

InChI Key: InChIKey=AIJVXAYSTVLGQZ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 99683   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM99683 (US8501936, 184) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3cccc(c3)C3CCN(CC(N)=O)CC3)nc12 Show InChI InChI=1S/C26H28N6O3S/c1-36(34,35)22-9-7-19(8-10-22)23-6-3-13-32-25(23)29-26(30-32)28-21-5-2-4-20(16-21)18-11-14-31(15-12-18)17-24(27)33/h2-10,13,16,18H,11-12,14-15,17H2,1H3,(H2,27,33)(H,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	384	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. US Patent					Assay Description The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...				US Patent US8501936 (2013) BindingDB Entry DOI: 10.7270/Q22Z1455
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM99683 (US8501936, 184) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3cccc(c3)C3CCN(CC(N)=O)CC3)nc12 Show InChI InChI=1S/C26H28N6O3S/c1-36(34,35)22-9-7-19(8-10-22)23-6-3-13-32-25(23)29-26(30-32)28-21-5-2-4-20(16-21)18-11-14-31(15-12-18)17-24(27)33/h2-10,13,16,18H,11-12,14-15,17H2,1H3,(H2,27,33)(H,28,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20.2	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. US Patent					Assay Description The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...				US Patent US8501936 (2013) BindingDB Entry DOI: 10.7270/Q22Z1455
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM99683 (US8501936, 184) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3cccc(c3)C3CCN(CC(N)=O)CC3)nc12 Show InChI InChI=1S/C26H28N6O3S/c1-36(34,35)22-9-7-19(8-10-22)23-6-3-13-32-25(23)29-26(30-32)28-21-5-2-4-20(16-21)18-11-14-31(15-12-18)17-24(27)33/h2-10,13,16,18H,11-12,14-15,17H2,1H3,(H2,27,33)(H,28,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.410	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. US Patent					Assay Description The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...				US Patent US8501936 (2013) BindingDB Entry DOI: 10.7270/Q22Z1455
					More data for this Ligand-Target Pair