BDBM99767 US8501936, 283

SMILES: CN(C)C(=O)CN1CCC(CC1)c1ccc(Nc2nc3c(cccn3n2)-c2cnn(c2)-c2ccc(F)cc2)cc1

InChI Key: InChIKey=WRKUJCHNZTZQDY-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 99767   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM99767 (US8501936, 283) Show SMILES CN(C)C(=O)CN1CCC(CC1)c1ccc(Nc2nc3c(cccn3n2)-c2cnn(c2)-c2ccc(F)cc2)cc1 Show InChI InChI=1S/C30H31FN8O/c1-36(2)28(40)20-37-16-13-22(14-17-37)21-5-9-25(10-6-21)33-30-34-29-27(4-3-15-38(29)35-30)23-18-32-39(19-23)26-11-7-24(31)8-12-26/h3-12,15,18-19,22H,13-14,16-17,20H2,1-2H3,(H,33,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.37E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. US Patent					Assay Description The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...				US Patent US8501936 (2013) BindingDB Entry DOI: 10.7270/Q22Z1455
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM99767 (US8501936, 283) Show SMILES CN(C)C(=O)CN1CCC(CC1)c1ccc(Nc2nc3c(cccn3n2)-c2cnn(c2)-c2ccc(F)cc2)cc1 Show InChI InChI=1S/C30H31FN8O/c1-36(2)28(40)20-37-16-13-22(14-17-37)21-5-9-25(10-6-21)33-30-34-29-27(4-3-15-38(29)35-30)23-18-32-39(19-23)26-11-7-24(31)8-12-26/h3-12,15,18-19,22H,13-14,16-17,20H2,1-2H3,(H,33,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	46.0	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. US Patent					Assay Description The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...				US Patent US8501936 (2013) BindingDB Entry DOI: 10.7270/Q22Z1455
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM99767 (US8501936, 283) Show SMILES CN(C)C(=O)CN1CCC(CC1)c1ccc(Nc2nc3c(cccn3n2)-c2cnn(c2)-c2ccc(F)cc2)cc1 Show InChI InChI=1S/C30H31FN8O/c1-36(2)28(40)20-37-16-13-22(14-17-37)21-5-9-25(10-6-21)33-30-34-29-27(4-3-15-38(29)35-30)23-18-32-39(19-23)26-11-7-24(31)8-12-26/h3-12,15,18-19,22H,13-14,16-17,20H2,1-2H3,(H,33,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.06	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. US Patent					Assay Description The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...				US Patent US8501936 (2013) BindingDB Entry DOI: 10.7270/Q22Z1455
					More data for this Ligand-Target Pair