BDBM50173765 BPH-308::CHEMBL196749::[2-(2',4'-Difluoro-biphenyl-3-yl)-1-hydroxy-1-phosphono-ethyl]-phosphonic acid

SMILES: OC(Cc1cccc(c1)-c1ccc(F)cc1F)(P(O)(O)=O)P(O)(O)=O

InChI Key: InChIKey=SQJZGUCJSOQOMH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50173765   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vacuolar-type proton translocating pyrophosphatase 1 (Trypanosoma brucei)	BDBM50173765 (BPH-308 | CHEMBL196749 | [2-(2',4'-Difluoro-biphen...) Show SMILES OC(Cc1cccc(c1)-c1ccc(F)cc1F)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C14H14F2O7P2/c15-11-4-5-12(13(16)7-11)10-3-1-2-9(6-10)8-14(17,24(18,19)20)25(21,22)23/h1-7,17H,8H2,(H2,18,19,20)(H2,21,22,23)	UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.38E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Urbana-Champaign Curated by ChEMBL					Assay Description Inhibition of recombinant Trypanosoma brucei soluble vacuolar pyrophosphatase expressed in Escherichia coli				J Med Chem 48: 6128-39 (2005) Article DOI: 10.1021/jm058220g BindingDB Entry DOI: 10.7270/Q2F47PX2
					More data for this Ligand-Target Pair
cis-Decaprenyl diphosphate synthase (cis-DPPS) (Mycobacterium tuberculosis H37Rv)	BDBM50173765 (BPH-308 | CHEMBL196749 | [2-(2',4'-Difluoro-biphen...) Show SMILES OC(Cc1cccc(c1)-c1ccc(F)cc1F)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C14H14F2O7P2/c15-11-4-5-12(13(16)7-11)10-3-1-2-9(6-10)8-14(17,24(18,19)20)25(21,22)23/h1-7,17H,8H2,(H2,18,19,20)(H2,21,22,23)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	7.5	n/a
University of California San Diego					Assay Description We screened an in-house library of 53 compounds using trans-FPP as substrate. Briefly, the condensation of IPP and GPP, FPP, or cis-FPP catalyzed by ...				Chem Biol Drug Des 85: 756-69 (2015) Article DOI: 10.1111/cbdd.12463 BindingDB Entry DOI: 10.7270/Q2ZG6QZN
					More data for this Ligand-Target Pair