BindingDB PrimarySearch

BDBM50016018 (S)-11-methoxy-7-methyl-6,7,7a,8-tetrahydro-5H-benzo[g][1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]quinolin-12-ol::11-Methoxy-7-methyl-6,7,7a,8-tetrahydro-5H-benzo[g][1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]quinolin-12-ol (Bulbocapnine)::Bulbocapnine::CHEMBL157912

SMILES: COc1ccc2C[C@@H]3N(C)CCc4cc5OCOc5c(c34)-c2c1O

InChI Key: InChIKey=LODGIKWNLDQZBM-LBPRGKRZSA-N

Data: 5 KI 4 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50016018
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
DRD1 (BOVINE)	BDBM50016018 ((S)-11-methoxy-7-methyl-6,7,7a,8-tetrahydro-5H-ben...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP K_i Database									Mol Pharmacol 12: 800-12 (1976) BindingDB Entry DOI: 10.7270/Q22B8WH6
TBA Curated by PDSP K_i Database					More data for this Ligand-Target Pair
D(2) dopamine receptor (BOVINE)	BDBM50016018 ((S)-11-methoxy-7-methyl-6,7,7a,8-tetrahydro-5H-ben...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	930	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP K_i Database									Mol Pharmacol 12: 800-12 (1976) BindingDB Entry DOI: 10.7270/Q22B8WH6
TBA Curated by PDSP K_i Database					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50016018 ((S)-11-methoxy-7-methyl-6,7,7a,8-tetrahydro-5H-ben...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neuroscience Research Centre Curated by PDSP K_i Database									J Pharmacol Exp Ther 268: 417-26 (1994) Article DOI: 10.1016/j.bioorg.2015.06.003 BindingDB Entry DOI: 10.7270/Q2C827SR
Neuroscience Research Centre Curated by PDSP K_i Database					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50016018 ((S)-11-methoxy-7-methyl-6,7,7a,8-tetrahydro-5H-ben...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	5.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neuroscience Research Centre Curated by PDSP K_i Database									J Pharmacol Exp Ther 268: 417-26 (1994) Article DOI: 10.1016/j.bioorg.2015.06.003 BindingDB Entry DOI: 10.7270/Q2C827SR
Neuroscience Research Centre Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Beta-2 adrenergic receptor (Homo sapiens (Human))	BDBM50016018 ((S)-11-methoxy-7-methyl-6,7,7a,8-tetrahydro-5H-ben...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP K_i Database									Mol Pharmacol 12: 568-80 (1976) BindingDB Entry DOI: 10.7270/Q2ZK5F5P
TBA Curated by PDSP K_i Database					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50016018 ((S)-11-methoxy-7-methyl-6,7,7a,8-tetrahydro-5H-ben...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	740	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Displacement of [3H]SCH-23390 from rat dopamine D1 receptor				J Med Chem 50: 171-81 (2007) Article DOI: 10.1021/jm060959i BindingDB Entry DOI: 10.7270/Q22J6CPJ
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50016018 ((S)-11-methoxy-7-methyl-6,7,7a,8-tetrahydro-5H-ben...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity towards rat Dopamine receptor D2 by [3H]-spiperone displacement.				J Med Chem 33: 600-7 (1990) BindingDB Entry DOI: 10.7270/Q2XS5TCP
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50016018 ((S)-11-methoxy-7-methyl-6,7,7a,8-tetrahydro-5H-ben...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	739	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity towards rat Dopamine receptor D1 by [3H]-SCH-23,390 displacement.				J Med Chem 33: 600-7 (1990) BindingDB Entry DOI: 10.7270/Q2XS5TCP
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50016018 ((S)-11-methoxy-7-methyl-6,7,7a,8-tetrahydro-5H-ben...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Displacement of [3H]raclopride from rat dopamine D2 receptor				J Med Chem 50: 171-81 (2007) Article DOI: 10.1021/jm060959i BindingDB Entry DOI: 10.7270/Q22J6CPJ
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair