BindingDB PrimarySearch

BDBM50090505 (1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione::(1R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione::(1S,2R,6S,7R)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione::(1S,3S,4R,7R)-2,6-dimethyl-4,10-dioxa-tricyclo[5.2.1.0-2,6]decane-3,5-dione::CANTHARIDIN::CHEMBL48449::cid_6708701

SMILES: C[C@]12[C@@H]3CC[C@@H](O3)[C@@]1(C)C(=O)OC2=O

InChI Key: InChIKey=DHZBEENLJMYSHQ-XCVPVQRUSA-N

Data: 12 IC50 1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50090505
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50090505 ((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	272	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay					Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2QN656Q
					More data for this Ligand-Target Pair
BZLF1 (Human herpesvirus 4)	BDBM50090505 ((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	239	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay					Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2BC3X0T
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 (Homo sapiens (Human))	BDBM50090505 ((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	>3.50E+5	n/a	n/a	n/a	n/a
Broad Institute Curated by PubChem BioAssay					Assay Description Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q24J0CKJ
Broad Institute Curated by PubChem BioAssay					More data for this Ligand-Target Pair
Serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alpha isoform (Mus musculus)	BDBM50090505 ((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for inhibitory concentration of Protein Phosphatase 2A (PP2A).				Bioorg Med Chem Lett 6: 1025-1028 (1996) Article DOI: 10.1016/0960-894X(96)00166-7 BindingDB Entry DOI: 10.7270/Q2Q52Q43
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Protein phosphatase 2C beta (Homo sapiens (Human))	BDBM50090505 ((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.78E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against recombinant Protein phosphatase 1				Bioorg Med Chem Lett 10: 1687-90 (2000) BindingDB Entry DOI: 10.7270/Q2GQ6Z8N
The University of Newcastle Curated by ChEMBL					More data for this Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit (Gallus gallus)	BDBM50090505 ((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against partially purified (chicken skeletal muscle) Protein phosphatase 2A				Bioorg Med Chem Lett 10: 1687-90 (2000) BindingDB Entry DOI: 10.7270/Q2GQ6Z8N
The University of Newcastle Curated by ChEMBL					More data for this Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit (Gallus gallus)	BDBM50090505 ((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)				J Med Chem 45: 1151-75 (2002) BindingDB Entry DOI: 10.7270/Q2DJ5GCG
The University of Newcastle Curated by ChEMBL					More data for this Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit (Gallus gallus)	BDBM50090505 ((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Concentration required to inhibit the action of protein phosphatase 2A				Bioorg Med Chem Lett 12: 391-3 (2002) BindingDB Entry DOI: 10.7270/Q2XS5VX8
The University of Newcastle Curated by ChEMBL					More data for this Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit (Gallus gallus)	BDBM50090505 ((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory concentration against protein phosphatase 2A was determined				Bioorg Med Chem Lett 11: 2941-6 (2001) BindingDB Entry DOI: 10.7270/Q24T6JX4
The University of Newcastle Curated by ChEMBL					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (Homo sapiens (Human))	BDBM50090505 ((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory concentration against protein phosphatase 1 was determined				Bioorg Med Chem Lett 11: 2941-6 (2001) BindingDB Entry DOI: 10.7270/Q24T6JX4
The University of Newcastle Curated by ChEMBL					More data for this Ligand-Target Pair
Serine-threonine protein phosphatase 2A regulatory subunit (Gallus gallus)	BDBM50090505 ((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of Serine/threonine protein phosphatase 2A by anhydride modified Cantharidin analogues				J Med Chem 45: 1151-75 (2002) BindingDB Entry DOI: 10.7270/Q2DJ5GCG
The University of Newcastle Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine protein phosphatase PP1-gamma catalytic subunit (Homo sapiens (Human))	BDBM50090505 ((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.78E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of Serine/threonine protein phosphatase 1 by anhydride modified Cantharidin analogues				J Med Chem 45: 1151-75 (2002) BindingDB Entry DOI: 10.7270/Q2DJ5GCG
The University of Newcastle Curated by ChEMBL					More data for this Ligand-Target Pair
Protein phosphatase 2C beta (Homo sapiens (Human))	BDBM50090505 ((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
University of California at Irvine Curated by ChEMBL					Assay Description Inhibitory activity against protein phosphatase-1 from rabbit skeletal muscle				Bioorg Med Chem Lett 14: 1969-73 (2004) Article DOI: 10.1016/j.bmcl.2004.01.093 BindingDB Entry DOI: 10.7270/Q25H7GTJ
University of California at Irvine Curated by ChEMBL					More data for this Ligand-Target Pair