BDBM50018268 CHEMBL3290307

SMILES: COc1ccc(cc1)-n1c2c(cnc3ccc(cc23)-c2ccncc2)n(C)c1=O

InChI Key: InChIKey=RVRKWOCAZWNINC-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50018268   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50018268 (CHEMBL3290307) Show SMILES COc1ccc(cc1)-n1c2c(cnc3ccc(cc23)-c2ccncc2)n(C)c1=O Show InChI InChI=1S/C23H18N4O2/c1-26-21-14-25-20-8-3-16(15-9-11-24-12-10-15)13-19(20)22(21)27(23(26)28)17-4-6-18(29-2)7-5-17/h3-14H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of human recombinant mTOR assessed as inhibition of 4EBP1 phosphorylation after 30 mins by TR-FRET analysis				J Med Chem 57: 4834-48 (2014) Article DOI: 10.1021/jm500361r BindingDB Entry DOI: 10.7270/Q2CJ8G1T
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50018268 (CHEMBL3290307) Show SMILES COc1ccc(cc1)-n1c2c(cnc3ccc(cc23)-c2ccncc2)n(C)c1=O Show InChI InChI=1S/C23H18N4O2/c1-26-21-14-25-20-8-3-16(15-9-11-24-12-10-15)13-19(20)22(21)27(23(26)28)17-4-6-18(29-2)7-5-17/h3-14H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	501	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of human PI3K-alpha assessed as inhibition of Ptdlns(3,4,5)P3 phosphorylation after 1 hr by TR-FRET analysis				J Med Chem 57: 4834-48 (2014) Article DOI: 10.1021/jm500361r BindingDB Entry DOI: 10.7270/Q2CJ8G1T
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50018268 (CHEMBL3290307) Show SMILES COc1ccc(cc1)-n1c2c(cnc3ccc(cc23)-c2ccncc2)n(C)c1=O Show InChI InChI=1S/C23H18N4O2/c1-26-21-14-25-20-8-3-16(15-9-11-24-12-10-15)13-19(20)22(21)27(23(26)28)17-4-6-18(29-2)7-5-17/h3-14H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of human PI3K-delta assessed as inhibition of Ptdlns(3,4,5)P3 phosphorylation after 1 hr by TR-FRET analysis				J Med Chem 57: 4834-48 (2014) Article DOI: 10.1021/jm500361r BindingDB Entry DOI: 10.7270/Q2CJ8G1T
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM50018268 (CHEMBL3290307) Show SMILES COc1ccc(cc1)-n1c2c(cnc3ccc(cc23)-c2ccncc2)n(C)c1=O Show InChI InChI=1S/C23H18N4O2/c1-26-21-14-25-20-8-3-16(15-9-11-24-12-10-15)13-19(20)22(21)27(23(26)28)17-4-6-18(29-2)7-5-17/h3-14H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	316	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of human PI3K-gamma assessed as inhibition of Ptdlns(3,4,5)P3 phosphorylation after 1 hr by TR-FRET analysis				J Med Chem 57: 4834-48 (2014) Article DOI: 10.1021/jm500361r BindingDB Entry DOI: 10.7270/Q2CJ8G1T
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM50018268 (CHEMBL3290307) Show SMILES COc1ccc(cc1)-n1c2c(cnc3ccc(cc23)-c2ccncc2)n(C)c1=O Show InChI InChI=1S/C23H18N4O2/c1-26-21-14-25-20-8-3-16(15-9-11-24-12-10-15)13-19(20)22(21)27(23(26)28)17-4-6-18(29-2)7-5-17/h3-14H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.94E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of human PI3K-beta assessed as inhibition of Ptdlns(3,4,5)P3 phosphorylation after 1 hr by TR-FRET analysis				J Med Chem 57: 4834-48 (2014) Article DOI: 10.1021/jm500361r BindingDB Entry DOI: 10.7270/Q2CJ8G1T
					More data for this Ligand-Target Pair