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BDBM50064301 CHEMBL3403665

SMILES: COc1c(-c2ccccc2)c(nc2ccc(F)cc12)[C@H](C)Nc1ncnc(N)c1C#N

InChI Key: InChIKey=QLGKYVWPTGEGNH-ZDUSSCGKSA-N

Data: 5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50064301
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50064301 (CHEMBL3403665) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assay				Bioorg Med Chem Lett 25: 1104-9 (2015) Article DOI: 10.1016/j.bmcl.2015.01.001 BindingDB Entry DOI: 10.7270/Q2H41T39
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50064301 (CHEMBL3403665) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta (unknown origin) by biochemical Alphascreen assay				Bioorg Med Chem Lett 25: 1104-9 (2015) Article DOI: 10.1016/j.bmcl.2015.01.001 BindingDB Entry DOI: 10.7270/Q2H41T39
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50064301 (CHEMBL3403665) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of PI3Kalpha (unknown origin) by biochemical Alphascreen assay				Bioorg Med Chem Lett 25: 1104-9 (2015) Article DOI: 10.1016/j.bmcl.2015.01.001 BindingDB Entry DOI: 10.7270/Q2H41T39
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM50064301 (CHEMBL3403665) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of PI3Kbeta (unknown origin) by biochemical Alphascreen assay				Bioorg Med Chem Lett 25: 1104-9 (2015) Article DOI: 10.1016/j.bmcl.2015.01.001 BindingDB Entry DOI: 10.7270/Q2H41T39
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM50064301 (CHEMBL3403665) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of PI3Kgamma (unknown origin) by biochemical Alphascreen assay				Bioorg Med Chem Lett 25: 1104-9 (2015) Article DOI: 10.1016/j.bmcl.2015.01.001 BindingDB Entry DOI: 10.7270/Q2H41T39
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair