BindingDB PrimarySearch

BDBM50067212 CHEBI:8093::Cyclomydril::Duo-Medihaler::PHENYLEPHRINE::Phenylephrine

SMILES: CNC[C@H](O)c1cccc(O)c1

InChI Key: InChIKey=SONNWYBIRXJNDC-VIFPVBQESA-N

Data: 8 KI 4 IC50 9 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50067212
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Alpha adrenergic receptor 1A and 1D (Rattus norvegicus (Rat))	BDBM50067212 (CHEBI:8093 \| Cyclomydril \| Duo-Medihaler \| PHENYLE...) Show SMILES CNC[C@H](O)c1cccc(O)c1 \|r\| Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	Article PubMed	162	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity towards rat clonal Alpha-1D adrenergic receptor				J Med Chem 39: 4116-9 (1996) Article DOI: 10.1021/jm960354u BindingDB Entry DOI: 10.7270/Q2FN18WJ
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50067212 (CHEBI:8093 \| Cyclomydril \| Duo-Medihaler \| PHENYLE...) Show SMILES CNC[C@H](O)c1cccc(O)c1 \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]clonidine from Alpha-2 adrenergic receptor of rat brain membranes				J Med Chem 25: 1389-401 (1982) BindingDB Entry DOI: 10.7270/Q2251MCQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (Homo sapiens (Human))	BDBM50067212 (CHEBI:8093 \| Cyclomydril \| Duo-Medihaler \| PHENYLE...) Show SMILES CNC[C@H](O)c1cccc(O)c1 \|r\| Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	390	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for its ability to displace [3H]clonidine form alpha-2 adrenergic receptor site in guinea pig cerebral cortical membranes.				J Med Chem 29: 1982-8 (1986) BindingDB Entry DOI: 10.7270/Q24M96QC
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM50067212 (CHEBI:8093 \| Cyclomydril \| Duo-Medihaler \| PHENYLE...) Show SMILES CNC[C@H](O)c1cccc(O)c1 \|r\| Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	450	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP K_i Database									Mol Pharmacol 13: 454-73 (1977) BindingDB Entry DOI: 10.7270/Q2TT4PFZ
TBA Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Cerebral cortex alpha adrenergic receptor (CALF)	BDBM50067212 (CHEBI:8093 \| Cyclomydril \| Duo-Medihaler \| PHENYLE...) Show SMILES CNC[C@H](O)c1cccc(O)c1 \|r\| Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	Article PubMed	933	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity towards bovine clonal Alpha-1A adrenergic receptor				J Med Chem 39: 4116-9 (1996) Article DOI: 10.1021/jm960354u BindingDB Entry DOI: 10.7270/Q2FN18WJ
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM50067212 (CHEBI:8093 \| Cyclomydril \| Duo-Medihaler \| PHENYLE...) Show SMILES CNC[C@H](O)c1cccc(O)c1 \|r\| Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	Article PubMed	977	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity towards Alpha-1A adrenergic receptor in rat submaxillary glands				J Med Chem 39: 4116-9 (1996) Article DOI: 10.1021/jm960354u BindingDB Entry DOI: 10.7270/Q2FN18WJ
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
adrenergic Alpha1 (HAMSTER)	BDBM50067212 (CHEBI:8093 \| Cyclomydril \| Duo-Medihaler \| PHENYLE...) Show SMILES CNC[C@H](O)c1cccc(O)c1 \|r\| Show InChI	GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	Article PubMed	1.26E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity towards hamster clonal Alpha-1B adrenergic receptor				J Med Chem 39: 4116-9 (1996) Article DOI: 10.1021/jm960354u BindingDB Entry DOI: 10.7270/Q2FN18WJ
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM50067212 (CHEBI:8093 \| Cyclomydril \| Duo-Medihaler \| PHENYLE...) Show SMILES CNC[C@H](O)c1cccc(O)c1 \|r\| Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP K_i Database									Mol Pharmacol 13: 454-73 (1977) BindingDB Entry DOI: 10.7270/Q2TT4PFZ
TBA Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM50067212 (CHEBI:8093 \| Cyclomydril \| Duo-Medihaler \| PHENYLE...) Show SMILES CNC[C@H](O)c1cccc(O)c1 \|r\| Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.66E+3	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens				J Med Chem 39: 4116-9 (1996) Article DOI: 10.1021/jm960354u BindingDB Entry DOI: 10.7270/Q2FN18WJ
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50067212 (CHEBI:8093 \| Cyclomydril \| Duo-Medihaler \| PHENYLE...) Show SMILES CNC[C@H](O)c1cccc(O)c1 \|r\| Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	2.95E+3	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate				J Med Chem 39: 4116-9 (1996) Article DOI: 10.1021/jm960354u BindingDB Entry DOI: 10.7270/Q2FN18WJ
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha adrenergic receptor 1A and 1B (Rattus norvegicus (rat))	BDBM50067212 (CHEBI:8093 \| Cyclomydril \| Duo-Medihaler \| PHENYLE...) Show SMILES CNC[C@H](O)c1cccc(O)c1 \|r\| Show InChI	Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro agonist potency towards Alpha-1B adrenergic receptor in rat spleen				J Med Chem 39: 4116-9 (1996) Article DOI: 10.1021/jm960354u BindingDB Entry DOI: 10.7270/Q2FN18WJ
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha adrenergic receptor 1A and 1D (Rattus norvegicus (Rat))	BDBM50067212 (CHEBI:8093 \| Cyclomydril \| Duo-Medihaler \| PHENYLE...) Show SMILES CNC[C@H](O)c1cccc(O)c1 \|r\| Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	155	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta				J Med Chem 39: 4116-9 (1996) Article DOI: 10.1021/jm960354u BindingDB Entry DOI: 10.7270/Q2FN18WJ
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50067212 (CHEBI:8093 \| Cyclomydril \| Duo-Medihaler \| PHENYLE...) Show SMILES CNC[C@H](O)c1cccc(O)c1 \|r\| Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	56	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Intrinsic activity at alpha1A adrenergic receptor (unknown origin) after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assa...				Bioorg Med Chem 24: 5582-5591 (2016) Article DOI: 10.1016/j.bmc.2016.09.017 BindingDB Entry DOI: 10.7270/Q20K2BJJ
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50067212 (CHEBI:8093 \| Cyclomydril \| Duo-Medihaler \| PHENYLE...) Show SMILES CNC[C@H](O)c1cccc(O)c1 \|r\| Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.19E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Inhibition of HIV1 RT				J Nat Prod 54: 143-54 Article DOI: 10.1021/np50073a012 BindingDB Entry DOI: 10.7270/Q2NK3HTG
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor beta (Homo sapiens (Human))	BDBM50067212 (CHEBI:8093 \| Cyclomydril \| Duo-Medihaler \| PHENYLE...) Show SMILES CNC[C@H](O)c1cccc(O)c1 \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of H-Ras-mediated farnesylation expressed in mouse NIH3T3 cells				J Med Chem 25: 680-4 (1982) BindingDB Entry DOI: 10.7270/Q24X59ZB
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50067212 (CHEBI:8093 \| Cyclomydril \| Duo-Medihaler \| PHENYLE...) Show SMILES CNC[C@H](O)c1cccc(O)c1 \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
Reckitt& Colman plc Curated by ChEMBL					Assay Description Inhibitory activity against Alpha-2 adrenergic receptor in rat vas deferens				J Med Chem 32: 1627-30 (1989) BindingDB Entry DOI: 10.7270/Q28S4S4V
Reckitt& Colman plc Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50067212 (CHEBI:8093 \| Cyclomydril \| Duo-Medihaler \| PHENYLE...) Show SMILES CNC[C@H](O)c1cccc(O)c1 \|r\| Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of specific [3H]prazosin binding (0.2 nM) to rat brain membranes alpha-1 adrenergic receptor				J Med Chem 27: 495-503 (1984) BindingDB Entry DOI: 10.7270/Q24B31WH
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50067212 (CHEBI:8093 \| Cyclomydril \| Duo-Medihaler \| PHENYLE...) Show SMILES CNC[C@H](O)c1cccc(O)c1 \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	520	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description 50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranes				J Med Chem 27: 495-503 (1984) BindingDB Entry DOI: 10.7270/Q24B31WH
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic alpha1B (Homo sapiens (Human))	BDBM50067212 (CHEBI:8093 \| Cyclomydril \| Duo-Medihaler \| PHENYLE...) Show SMILES CNC[C@H](O)c1cccc(O)c1 \|r\| Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.90	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Agonist activity at alpha-1B adrenergic receptor (unknown origin) after 5 hrs by CCF4-AM staining-based cellular assay				Bioorg Med Chem 23: 2104-11 (2015) Article DOI: 10.1016/j.bmc.2015.03.009 BindingDB Entry DOI: 10.7270/Q2W37Z0Z
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50067212 (CHEBI:8093 \| Cyclomydril \| Duo-Medihaler \| PHENYLE...) Show SMILES CNC[C@H](O)c1cccc(O)c1 \|r\| Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	55	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Agonist activity at alpha-1A adrenergic receptor (unknown origin) after 5 hrs by CCF4-AM staining-based cellular assay				Bioorg Med Chem 23: 2104-11 (2015) Article DOI: 10.1016/j.bmc.2015.03.009 BindingDB Entry DOI: 10.7270/Q2W37Z0Z
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic alpha1B (Homo sapiens (Human))	BDBM50067212 (CHEBI:8093 \| Cyclomydril \| Duo-Medihaler \| PHENYLE...) Show SMILES CNC[C@H](O)c1cccc(O)c1 \|r\| Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.860	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Intrinsic activity at human alpha1B adrenergic receptor expressed in CHOK1 cells co-expressing aequorin assessed as calcium mobilization measured for...				Bioorg Med Chem 24: 5582-5591 (2016) Article DOI: 10.1016/j.bmc.2016.09.017 BindingDB Entry DOI: 10.7270/Q20K2BJJ
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair