BDBM50173534 ({[5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy}carbonyl)(sulfamoyl)azanide::CHEMBL3144294::Deoxyuridine

SMILES: NS(=O)(=O)NC(=O)OC[C@H]1O[C@H](C[C@@H]1O)n1ccc(=O)[nH]c1=O

InChI Key: InChIKey=YVQFWCFJXBRAQK-UHFFFAOYSA-M

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50173534   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
dUTP pyrophosphatase (Leishmania major)	BDBM50173534 (({[5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-...) Show SMILES NS(=O)(=O)NC(=O)OC[C@H]1O[C@H](C[C@@H]1O)n1ccc(=O)[nH]c1=O |r| Show InChI InChI=1S/C10H14N4O8S/c11-23(19,20)13-10(18)21-4-6-5(15)3-8(22-6)14-2-1-7(16)12-9(14)17/h1-2,5-6,8,15H,3-4H2,(H4,11,12,13,16,17,18,19,20)/p-1	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.14E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cardiff University Curated by ChEMBL					Assay Description Inhibitory constant against Leishmania major deoxyuridine 5'-triphosphate nucleotidohydrolase				J Med Chem 48: 5942-54 (2005) Article DOI: 10.1021/jm050111e BindingDB Entry DOI: 10.7270/Q2Z320DG
					More data for this Ligand-Target Pair
dUTP pyrophosphatase (Plasmodium falciparum)	BDBM50173534 (({[5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-...) Show SMILES NS(=O)(=O)NC(=O)OC[C@H]1O[C@H](C[C@@H]1O)n1ccc(=O)[nH]c1=O |r| Show InChI InChI=1S/C10H14N4O8S/c11-23(19,20)13-10(18)21-4-6-5(15)3-8(22-6)14-2-1-7(16)12-9(14)17/h1-2,5-6,8,15H,3-4H2,(H4,11,12,13,16,17,18,19,20)/p-1	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.68E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cardiff University Curated by ChEMBL					Assay Description Inhibitory constant against Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in Escherichia coli BL21 (DE3) cells				J Med Chem 48: 5942-54 (2005) Article DOI: 10.1021/jm050111e BindingDB Entry DOI: 10.7270/Q2Z320DG
					More data for this Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (Homo sapiens (Human))	BDBM50173534 (({[5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-...) Show SMILES NS(=O)(=O)NC(=O)OC[C@H]1O[C@H](C[C@@H]1O)n1ccc(=O)[nH]c1=O |r| Show InChI InChI=1S/C10H14N4O8S/c11-23(19,20)13-10(18)21-4-6-5(15)3-8(22-6)14-2-1-7(16)12-9(14)17/h1-2,5-6,8,15H,3-4H2,(H4,11,12,13,16,17,18,19,20)/p-1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cardiff University Curated by ChEMBL					Assay Description Inhibitory constant against human deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in Escherichia coli BL21 (DE3) cells				J Med Chem 48: 5942-54 (2005) Article DOI: 10.1021/jm050111e BindingDB Entry DOI: 10.7270/Q2Z320DG
					More data for this Ligand-Target Pair