BDBM50101816 CHEBI:8107::Dilabid::Dilantin::Dilantin-125::Dilantin-30::Diphenylhydantoin::Hydantol::PHENYTOIN::Phentytoin::Phenytek::Phenytex::Phenytoin

SMILES: OC1=NC(=O)C(N1)(c1ccccc1)c1ccccc1

InChI Key: InChIKey=CXOFVDLJLONNDW-UHFFFAOYSA-N

Data: 1 KI  8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50101816   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 2 alpha subunit (Homo sapiens (Human))	BDBM50101816 (CHEBI:8107 | Dilabid | Dilantin | Dilantin-125 | D...) Show SMILES OC1=NC(=O)C(N1)(c1ccccc1)c1ccccc1 |t:1| Show InChI InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article	5.34E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to Nav 1.2 (unknown origin)				Citation and Details Article DOI: 10.1007/s00044-012-0256-y BindingDB Entry DOI: 10.7270/Q20P12XT
					More data for this Ligand-Target Pair
Calcium channel (Type L) (Homo sapiens (Human))	BDBM50101816 (CHEBI:8107 | Dilabid | Dilantin | Dilantin-125 | D...) Show SMILES OC1=NC(=O)C(N1)(c1ccccc1)c1ccccc1 |t:1| Show InChI InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.25E+5	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C sub...				J Appl Toxicol 32: 858-66 (2012) Article DOI: 10.1002/jat.2784 BindingDB Entry DOI: 10.7270/Q2D79D5C
					More data for this Ligand-Target Pair
Sodium channel protein type I I alpha subunit (Rattus norvegicus)	BDBM50101816 (CHEBI:8107 | Dilabid | Dilantin | Dilantin-125 | D...) Show SMILES OC1=NC(=O)C(N1)(c1ccccc1)c1ccccc1 |t:1| Show InChI InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description In vitro inhibition of [3H]-BTX-B binding to sodium channels in rat brain synapto-neurosomes				J Med Chem 31: 2218-21 (1988) BindingDB Entry DOI: 10.7270/Q2MC927C
					More data for this Ligand-Target Pair
Sodium channel protein type I I alpha subunit (Rattus norvegicus)	BDBM50101816 (CHEBI:8107 | Dilabid | Dilantin | Dilantin-125 | D...) Show SMILES OC1=NC(=O)C(N1)(c1ccccc1)c1ccccc1 |t:1| Show InChI InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama at Birmingham Curated by ChEMBL					Assay Description Inhibition of [3H]BTX-B binding to Neuronal voltage-dependent sodium channel of rat cerebral cortex synaptoneurosomes				J Med Chem 40: 602-7 (1997) Article DOI: 10.1021/jm960692v BindingDB Entry DOI: 10.7270/Q2J96931
					More data for this Ligand-Target Pair
Sodium channel protein type I I alpha subunit (Rattus norvegicus)	BDBM50101816 (CHEBI:8107 | Dilabid | Dilantin | Dilantin-125 | D...) Show SMILES OC1=NC(=O)C(N1)(c1ccccc1)c1ccccc1 |t:1| Show InChI InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama at Birmingham Curated by ChEMBL					Assay Description In vitro inhibition of Voltage-gated sodium channel by the displacement of [3H]batrachotoxin A 20-alpha-benzoate in rat brain cerebral cortex synapto...				J Med Chem 42: 1537-45 (1999) Article DOI: 10.1021/jm980556l BindingDB Entry DOI: 10.7270/Q2RJ4N61
					More data for this Ligand-Target Pair
Sodium channel protein type I I alpha subunit (Rattus norvegicus)	BDBM50101816 (CHEBI:8107 | Dilabid | Dilantin | Dilantin-125 | D...) Show SMILES OC1=NC(=O)C(N1)(c1ccccc1)c1ccccc1 |t:1| Show InChI InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Howard University Curated by ChEMBL					Assay Description Inhibition of [3H]BTX-B binding to neurotoxin site 2 of sodium channel of rat cerebral cortex synaptoneurosomes				J Med Chem 38: 4033-43 (1995) Article DOI: 10.1021/jm00020a019 BindingDB Entry DOI: 10.7270/Q2DV1NM8
					More data for this Ligand-Target Pair
Sodium channel protein type I I alpha subunit (Rattus norvegicus)	BDBM50101816 (CHEBI:8107 | Dilabid | Dilantin | Dilantin-125 | D...) Show SMILES OC1=NC(=O)C(N1)(c1ccccc1)c1ccccc1 |t:1| Show InChI InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama at Birmingham Curated by ChEMBL					Assay Description Inhibition of binding to sodium channel of rat cerebral cortex				J Med Chem 37: 3289-93 (1994) Article DOI: 10.1021/jm00046a013 BindingDB Entry DOI: 10.7270/Q2NG4TB8
					More data for this Ligand-Target Pair
Voltage-dependent L-type calcium channel subunit alpha-1C (Cavia porcellus)	BDBM50101816 (CHEBI:8107 | Dilabid | Dilantin | Dilantin-125 | D...) Show SMILES OC1=NC(=O)C(N1)(c1ccccc1)c1ccccc1 |t:1| Show InChI InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)	UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.03E+5	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytes				J Appl Toxicol 32: 858-66 (2012) Article DOI: 10.1002/jat.2784 BindingDB Entry DOI: 10.7270/Q2D79D5C
					More data for this Ligand-Target Pair
Voltage-gated L-type calcium channel (Homo sapiens (Human))	BDBM50101816 (CHEBI:8107 | Dilabid | Dilantin | Dilantin-125 | D...) Show SMILES OC1=NC(=O)C(N1)(c1ccccc1)c1ccccc1 |t:1| Show InChI InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.19E+4	n/a	n/a	n/a	n/a	n/a	n/a
ChanTest Corporation Curated by ChEMBL					Assay Description Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits				Sci Rep 3: (2013) Article DOI: 10.1038/srep02100 BindingDB Entry DOI: 10.7270/Q2RB77K2
					More data for this Ligand-Target Pair