BDBM50328064 CHEMBL1258354::ETP-7382::N-(3-methoxyphenyl)-1-methyl-6-morpholino-1H-pyrazolo[3,4-d]pyrimidin-4-amine

SMILES: COc1cccc(Nc2nc(nc3n(C)ncc23)N2CCOCC2)c1

InChI Key: InChIKey=PVQFMGYIWGTZOO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50328064   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50328064 (CHEMBL1258354 | ETP-7382 | N-(3-methoxyphenyl)-1-m...) Show SMILES COc1cccc(Nc2nc(nc3n(C)ncc23)N2CCOCC2)c1 Show InChI InChI=1S/C17H20N6O2/c1-22-16-14(11-18-22)15(19-12-4-3-5-13(10-12)24-2)20-17(21-16)23-6-8-25-9-7-23/h3-5,10-11H,6-9H2,1-2H3,(H,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	162	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of PI3Kalpha				Bioorg Med Chem Lett 20: 6048-51 (2010) Article DOI: 10.1016/j.bmcl.2010.08.067 BindingDB Entry DOI: 10.7270/Q2ST7Q28
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50328064 (CHEMBL1258354 | ETP-7382 | N-(3-methoxyphenyl)-1-m...) Show SMILES COc1cccc(Nc2nc(nc3n(C)ncc23)N2CCOCC2)c1 Show InChI InChI=1S/C17H20N6O2/c1-22-16-14(11-18-22)15(19-12-4-3-5-13(10-12)24-2)20-17(21-16)23-6-8-25-9-7-23/h3-5,10-11H,6-9H2,1-2H3,(H,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Spanish National Cancer Research Center (CNIO)					Assay Description Kinase assay using PI3K.				J Biol Chem 284: 28392-400 (2009) Article DOI: 10.1074/jbc.M109.038984 BindingDB Entry DOI: 10.7270/Q2N01556
					More data for this Ligand-Target Pair