Found 13 hits for monomerid = 50241379 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Homo sapiens phosphodiesterase 2A (PDE2A)
(Homo sapiens (Human)) | BDBM50241379
((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)Show InChI InChI=1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16) | PDB
UniProtKB/SwissProt
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
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| n/a | n/a | 5.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of cyclic GMP sensitive phosphodiesterase PDE 2 of guinea pig ventricle |
J Med Chem 28: 537-45 (1985)
BindingDB Entry DOI: 10.7270/Q2N58MXT |
More data for this Ligand-Target Pair | |
Phosphodiesterase 4
(Homo sapiens (Human)) | BDBM50241379
((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)Show InChI InChI=1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
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Patents
| PubMed
| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merrell Dow Research Institute
Curated by ChEMBL
| Assay Description Inhibition of canine heart Phosphodiesterase 4 |
J Med Chem 33: 317-27 (1990)
BindingDB Entry DOI: 10.7270/Q27S7R0G |
More data for this Ligand-Target Pair | |
Phosphodiesterase 4
(Homo sapiens (Human)) | BDBM50241379
((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)Show InChI InChI=1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
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| n/a | n/a | >1.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merrell Dow Research Institute
Curated by ChEMBL
| Assay Description Inhibition of canine kidney Phosphodiesterase 4 |
J Med Chem 33: 317-27 (1990)
BindingDB Entry DOI: 10.7270/Q27S7R0G |
More data for this Ligand-Target Pair | |
Phosphodiesterase 3
(Homo sapiens (Human)) | BDBM50241379
((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)Show InChI InChI=1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16) | PDB MMDB
UniProtKB/SwissProt
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
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| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description Inhibition of cAMP PDE III enzyme |
J Med Chem 30: 1963-72 (1987)
BindingDB Entry DOI: 10.7270/Q28K79P9 |
More data for this Ligand-Target Pair | |
Phosphodiesterase 3
(Homo sapiens (Human)) | BDBM50241379
((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)Show InChI InChI=1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
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Patents
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| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of low Km cyclic cAMP phosphodiesterase PDE III of guinea pig ventricle |
J Med Chem 28: 537-45 (1985)
BindingDB Entry DOI: 10.7270/Q2N58MXT |
More data for this Ligand-Target Pair | |
Phosphodiesterase 1
(Homo sapiens (Human)) | BDBM50241379
((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)Show InChI InChI=1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16) | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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Patents
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| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of guinea pig ventricle |
J Med Chem 28: 537-45 (1985)
BindingDB Entry DOI: 10.7270/Q2N58MXT |
More data for this Ligand-Target Pair | |
Canalicular multispecific organic anion transporter 1
(Homo sapiens (Human)) | BDBM50241379
((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)Show InChI InChI=1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16) | UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
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| n/a | n/a | 1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and... |
Toxicol Sci 136: 216-41 (2013)
BindingDB Entry DOI: 10.7270/Q2JM2D2D |
More data for this Ligand-Target Pair | |
Phosphodiesterase 4
(Homo sapiens (Human)) | BDBM50241379
((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)Show InChI InChI=1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
| PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of canine cardiac cAMP phosphodiesterase (cAMP-PDE) |
J Med Chem 30: 1342-7 (1987)
BindingDB Entry DOI: 10.7270/Q2DV1N40 |
More data for this Ligand-Target Pair | |
Phosphodiesterase 3
(Homo sapiens (Human)) | BDBM50241379
((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)Show InChI InChI=1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16) | PDB MMDB
UniProtKB/SwissProt
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
| PubMed
| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of fraction III of guinea pig phosphodiesterase |
J Med Chem 27: 1099-101 (1984)
BindingDB Entry DOI: 10.7270/Q26Q1W70 |
More data for this Ligand-Target Pair | |
Bile salt export pump
(Homo sapiens (Human)) | BDBM50241379
((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)Show InChI InChI=1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
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| n/a | n/a | 1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ... |
Toxicol Sci 136: 216-41 (2013)
BindingDB Entry DOI: 10.7270/Q2JM2D2D |
More data for this Ligand-Target Pair | |
Multidrug resistance-associated protein 4
(Homo sapiens (Human)) | BDBM50241379
((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)Show InChI InChI=1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
| PubMed
| n/a | n/a | 1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and... |
Toxicol Sci 136: 216-41 (2013)
BindingDB Entry DOI: 10.7270/Q2JM2D2D |
More data for this Ligand-Target Pair | |
Canalicular multispecific organic anion transporter 2
(Homo sapiens (Human)) | BDBM50241379
((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)Show InChI InChI=1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
| PubMed
| n/a | n/a | 1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ... |
Toxicol Sci 136: 216-41 (2013)
BindingDB Entry DOI: 10.7270/Q2JM2D2D |
More data for this Ligand-Target Pair | |
Phosphodiesterase 3
(Homo sapiens (Human)) | BDBM50241379
((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)Show InChI InChI=1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
| PubMed
| n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity against sigma receptor |
J Med Chem 30: 303-18 (1987)
BindingDB Entry DOI: 10.7270/Q27946X0 |
More data for this Ligand-Target Pair | |