BDBM14771 (E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylidene}amino carbamate::Filaminast::[1-(3-cyclopentyloxy-4-methoxy-phenyl)ethylideneamino] carbamate

SMILES: COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O

InChI Key: InChIKey=STTRYQAGHGJXJJ-UHFFFAOYSA-N

Data: 12 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 14771   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM14771 ((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...) Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O |w:16.18| Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.90E+5	n/a	n/a	n/a	n/a	7.5	30
Plexxikon					Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...				Structure 12: 2233-47 (2004) Article DOI: 10.1016/j.str.2004.10.004 BindingDB Entry DOI: 10.7270/Q25B00Q1
					More data for this Ligand-Target Pair
Phosphodiesterase Type 2 (PDE2A) (Homo sapiens (Human))	BDBM14771 ((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...) Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O |w:16.18| Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	8.90E+4	n/a	n/a	n/a	n/a	7.5	30
Plexxikon					Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...				Structure 12: 2233-47 (2004) Article DOI: 10.1016/j.str.2004.10.004 BindingDB Entry DOI: 10.7270/Q25B00Q1
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (aa 650-1084) (Homo sapiens (Human))	BDBM14771 ((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...) Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O |w:16.18| Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	9.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon					Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...				Structure 12: 2233-47 (2004) Article DOI: 10.1016/j.str.2004.10.004 BindingDB Entry DOI: 10.7270/Q25B00Q1
					More data for this Ligand-Target Pair
Phosphodiesterase Type 4 (PDE4B) (Homo sapiens (Human))	BDBM14771 ((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...) Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O |w:16.18| Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)	PDB MMDB B.MOAD DrugBank GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents	MMDB PDB Article PubMed	n/a	n/a	960	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon					Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...				Structure 12: 2233-47 (2004) Article DOI: 10.1016/j.str.2004.10.004 BindingDB Entry DOI: 10.7270/Q25B00Q1
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphodiesterase Type 4 (PDE4D) (Homo sapiens (Human))	BDBM14771 ((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...) Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O |w:16.18| Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)	PDB MMDB B.MOAD GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon					Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...				Structure 12: 2233-47 (2004) Article DOI: 10.1016/j.str.2004.10.004 BindingDB Entry DOI: 10.7270/Q25B00Q1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM14771 ((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...) Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O |w:16.18| Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	960	n/a	n/a	n/a	n/a	n/a	n/a
King's College London Curated by ChEMBL					Assay Description Inhibition of human MAPK p38alpha				Bioorg Med Chem 18: 2204-18 (2010) Article DOI: 10.1016/j.bmc.2010.01.070 BindingDB Entry DOI: 10.7270/Q27945MJ
					More data for this Ligand-Target Pair
Phosphodiesterase Type 7 (PDE7B) (Homo sapiens (Human))	BDBM14771 ((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...) Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O |w:16.18| Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)	Reactome pathway KEGG DrugBank GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	990	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon					Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...				Structure 12: 2233-47 (2004) Article DOI: 10.1016/j.str.2004.10.004 BindingDB Entry DOI: 10.7270/Q25B00Q1
					More data for this Ligand-Target Pair
Phosphodiesterase 8 (Homo sapiens (Human))	BDBM14771 ((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...) Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O |w:16.18| Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon					Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...				Structure 12: 2233-47 (2004) Article DOI: 10.1016/j.str.2004.10.004 BindingDB Entry DOI: 10.7270/Q25B00Q1
					More data for this Ligand-Target Pair
Phosphodiesterase Type 9 (PDE9A) (Homo sapiens (Human))	BDBM14771 ((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...) Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O |w:16.18| Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon					Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...				Structure 12: 2233-47 (2004) Article DOI: 10.1016/j.str.2004.10.004 BindingDB Entry DOI: 10.7270/Q25B00Q1
					More data for this Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A) (Homo sapiens (Human))	BDBM14771 ((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...) Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O |w:16.18| Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon					Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...				Structure 12: 2233-47 (2004) Article DOI: 10.1016/j.str.2004.10.004 BindingDB Entry DOI: 10.7270/Q25B00Q1
					More data for this Ligand-Target Pair
Phosphodiesterase Type 11 (PDE11A) (Homo sapiens (Human))	BDBM14771 ((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...) Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O |w:16.18| Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)	GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	5.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon					Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...				Structure 12: 2233-47 (2004) Article DOI: 10.1016/j.str.2004.10.004 BindingDB Entry DOI: 10.7270/Q25B00Q1
					More data for this Ligand-Target Pair
Phosphodiesterase Type 5 (PDE5A) (Homo sapiens (Human))	BDBM14771 ((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...) Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O |w:16.18| Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	5.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon					Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...				Structure 12: 2233-47 (2004) Article DOI: 10.1016/j.str.2004.10.004 BindingDB Entry DOI: 10.7270/Q25B00Q1
					More data for this Ligand-Target Pair