BDBM9347 (2Z)-but-2-enedioic acid; 9-amino-1,2,3,4-tetrahydroacridin-1-ol::9-Amino-1 ,2,3,4-tetrahydroacridin-1-ol deriv. 1a::9-amino-1,2,3,4-tetrahydroacridin-1-ol maleate::CHEMBL23455::CHEMBL51934::HP-029
SMILES: Nc1c2C(O)CCCc2nc2ccccc12
InChI Key: InChIKey=HLVVITIHAZBPKB-UHFFFAOYSA-N
Data: 11 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Acetylcholinesterase (Rattus norvegicus (rat)) | BDBM9347![]() ((2Z)-but-2-enedioic acid; 9-amino-1,2,3,4-tetrahyd...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Hoechst-Roussel Pharmaceuticals, Inc. | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. | J Med Chem 32: 1805-13 (1989) Article DOI: 10.1021/jm00128a024 BindingDB Entry DOI: 10.7270/Q24Q7S6Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Butyrylcholinesterase (BChE) (Equus caballus (Horse)) | BDBM9347![]() ((2Z)-but-2-enedioic acid; 9-amino-1,2,3,4-tetrahyd...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article | n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of (BChE) Butyrylcholinesterase of horse serum | Bioorg Med Chem Lett 2: 861-864 (1992) Article DOI: 10.1016/S0960-894X(00)80545-4 BindingDB Entry DOI: 10.7270/Q29886XS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Homo sapiens (Human)) | BDBM9347![]() ((2Z)-but-2-enedioic acid; 9-amino-1,2,3,4-tetrahyd...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 702 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of Acetylcholinesterase in human red blood cell | J Med Chem 39: 3014-8 (1996) Article DOI: 10.1021/jm9602266 BindingDB Entry DOI: 10.7270/Q20V8BVM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Rattus norvegicus (rat)) | BDBM9347![]() ((2Z)-but-2-enedioic acid; 9-amino-1,2,3,4-tetrahyd...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst-Roussel Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description In vitro inhibitory activity against acetylcholinesterase using rat striatal preparations | J Med Chem 31: 1278-9 (1988) BindingDB Entry DOI: 10.7270/Q25D8QTS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM9347![]() ((2Z)-but-2-enedioic acid; 9-amino-1,2,3,4-tetrahyd...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of Acetylcholinesterase in mouse red blood cell | J Med Chem 39: 3014-8 (1996) Article DOI: 10.1021/jm9602266 BindingDB Entry DOI: 10.7270/Q20V8BVM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Rattus norvegicus (rat)) | BDBM9347![]() ((2Z)-but-2-enedioic acid; 9-amino-1,2,3,4-tetrahyd...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article | n/a | n/a | 3.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of acetylcholinesterase from rat striatal tissue | Bioorg Med Chem Lett 3: 2789-2792 (1993) Article DOI: 10.1016/S0960-894X(01)80765-4 BindingDB Entry DOI: 10.7270/Q2KD1XTB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Rattus norvegicus (rat)) | BDBM9347![]() ((2Z)-but-2-enedioic acid; 9-amino-1,2,3,4-tetrahyd...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 361 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of Acetylcholinesterase in rat red blood cell | J Med Chem 39: 3014-8 (1996) Article DOI: 10.1021/jm9602266 BindingDB Entry DOI: 10.7270/Q20V8BVM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Homo sapiens (Human)) | BDBM9347![]() ((2Z)-but-2-enedioic acid; 9-amino-1,2,3,4-tetrahyd...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article | n/a | n/a | 164 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of acetylcholinesterase (AChE) of human red blood cell (type XIII) by modified radiometric AChE assay | Bioorg Med Chem Lett 2: 861-864 (1992) Article DOI: 10.1016/S0960-894X(00)80545-4 BindingDB Entry DOI: 10.7270/Q29886XS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Electrophorus electricus (Electric eel)) | BDBM9347![]() ((2Z)-but-2-enedioic acid; 9-amino-1,2,3,4-tetrahyd...) | UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of acetylcholinesterase (AChE) in electric eel (type V-S) by modified radiometric assay | Bioorg Med Chem Lett 2: 861-864 (1992) Article DOI: 10.1016/S0960-894X(00)80545-4 BindingDB Entry DOI: 10.7270/Q29886XS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Rattus norvegicus (rat)) | BDBM9347![]() ((2Z)-but-2-enedioic acid; 9-amino-1,2,3,4-tetrahyd...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of acetylcholinesterase | Bioorg Med Chem Lett 2: 865-870 (1992) Article DOI: 10.1016/S0960-894X(00)80546-6 BindingDB Entry DOI: 10.7270/Q25H7G51 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Homo sapiens (Human)) | BDBM9347![]() ((2Z)-but-2-enedioic acid; 9-amino-1,2,3,4-tetrahyd...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 954 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of Acetylcholinesterase in monkey red blood cell | J Med Chem 39: 3014-8 (1996) Article DOI: 10.1021/jm9602266 BindingDB Entry DOI: 10.7270/Q20V8BVM | |||||||||||
More data for this Ligand-Target Pair |