BDBM50010283 2,7-difluorospiro[9H-fluorene-9,4'-(tetrahydro-1'H-imidazole)]-2',5'-dione::2,7-difluorospiro[9H-fluorene-9,4'-(tetrahydro-1'H-imidazole)]-2',5'-dione(imirestat)::CHEMBL269455::Imirestat

SMILES: Fc1ccc2-c3ccc(F)cc3C3(NC(=O)NC3=O)c2c1

InChI Key: InChIKey=QCCHBHSAIQIQGO-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50010283   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aldose reductase (Rattus norvegicus)	BDBM50010283 (2,7-difluorospiro[9H-fluorene-9,4'-(tetrahydro-1'H...) Show SMILES Fc1ccc2-c3ccc(F)cc3C3(NC(=O)NC3=O)c2c1 Show InChI InChI=1S/C15H8F2N2O2/c16-7-1-3-9-10-4-2-8(17)6-12(10)15(11(9)5-7)13(20)18-14(21)19-15/h1-6H,(H2,18,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)				J Med Chem 34: 3229-34 (1991) BindingDB Entry DOI: 10.7270/Q2QJ7HXM
					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50010283 (2,7-difluorospiro[9H-fluorene-9,4'-(tetrahydro-1'H...) Show SMILES Fc1ccc2-c3ccc(F)cc3C3(NC(=O)NC3=O)c2c1 Show InChI InChI=1S/C15H8F2N2O2/c16-7-1-3-9-10-4-2-8(17)6-12(10)15(11(9)5-7)13(20)18-14(21)19-15/h1-6H,(H2,18,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibition of Aldose reductase (AR) from rat lens (RL)				J Med Chem 34: 3229-34 (1991) BindingDB Entry DOI: 10.7270/Q2QJ7HXM
					More data for this Ligand-Target Pair
Aldose reductase (AR) (Homo sapiens (Human))	BDBM50010283 (2,7-difluorospiro[9H-fluorene-9,4'-(tetrahydro-1'H...) Show SMILES Fc1ccc2-c3ccc(F)cc3C3(NC(=O)NC3=O)c2c1 Show InChI InChI=1S/C15H8F2N2O2/c16-7-1-3-9-10-4-2-8(17)6-12(10)15(11(9)5-7)13(20)18-14(21)19-15/h1-6H,(H2,18,19,20,21)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	54.7	n/a	n/a	n/a	n/a	n/a	n/a
National Eye Institute Curated by ChEMBL					Assay Description Inhibitory Activity against Human recombinant Aldose Reductase (wild type)				J Med Chem 43: 1062-70 (2000) BindingDB Entry DOI: 10.7270/Q2QZ2BPN
					More data for this Ligand-Target Pair