BDBM50009719 7-Methyl-2-propyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine::CHEMBL296725::L-158338
SMILES: CCCc1nc2c(C)ccnc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
InChI Key: InChIKey=CYUMNDVYHILLEX-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Angiotensin II type 1a (AT-1a) receptor (RABBIT) | BDBM50009719![]() (7-Methyl-2-propyl-3-[2'-(2H-tetrazol-5-yl)-bipheny...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro binding affinity of the compound towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from th... | Bioorg Med Chem Lett 3: 1693-1696 (1993) Article DOI: 10.1016/S0960-894X(00)80044-X BindingDB Entry DOI: 10.7270/Q2CF9Q12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II AT1B (RAT) | BDBM50009719![]() (7-Methyl-2-propyl-3-[2'-(2H-tetrazol-5-yl)-bipheny...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Siena Curated by ChEMBL | Assay Description Binding affinity for rat angiotensin II receptor, type 1 | J Med Chem 47: 2574-86 (2004) Article DOI: 10.1021/jm031100t BindingDB Entry DOI: 10.7270/Q25X28DX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II receptor (Homo sapiens (Human)) | BDBM50009719![]() (7-Methyl-2-propyl-3-[2'-(2H-tetrazol-5-yl)-bipheny...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Exploratory Chemistry Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards Angiotensin receptor from rabbit aorta | J Med Chem 34: 2919-22 (1991) BindingDB Entry DOI: 10.7270/Q26Q20H6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II type 1a (AT-1a) receptor (RABBIT) | BDBM50009719![]() (7-Methyl-2-propyl-3-[2'-(2H-tetrazol-5-yl)-bipheny...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type ... | Bioorg Med Chem Lett 4: 17-22 (1994) Article DOI: 10.1016/S0960-894X(01)81115-X BindingDB Entry DOI: 10.7270/Q2G73DPF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II AT2 (RAT) | BDBM50009719![]() (7-Methyl-2-propyl-3-[2'-(2H-tetrazol-5-yl)-bipheny...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain m... | Bioorg Med Chem Lett 4: 17-22 (1994) Article DOI: 10.1016/S0960-894X(01)81115-X BindingDB Entry DOI: 10.7270/Q2G73DPF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II AT2 (RAT) | BDBM50009719![]() (7-Methyl-2-propyl-3-[2'-(2H-tetrazol-5-yl)-bipheny...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro binding affinity of the compound towards Angiotensin II receptor, type 2 determined as its ability to displace 125I-Sarl,Ile8-AII from the r... | Bioorg Med Chem Lett 3: 1693-1696 (1993) Article DOI: 10.1016/S0960-894X(00)80044-X BindingDB Entry DOI: 10.7270/Q2CF9Q12 | |||||||||||
More data for this Ligand-Target Pair |