BindingDB PrimarySearch

BDBM50366817 Epivir

SMILES: Nc1ccn([C@@H]2CS[C@H](CO)O2)c(=O)n1

InChI Key: InChIKey=JTEGQNOMFQHVDC-NKWVEPMBSA-N

Data: 7 IC50 1 Kd 3 EC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50366817
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50366817 (Epivir) Show SMILES Nc1ccn([C@@H]2CS[C@H](CO)O2)c(=O)n1 \|r\| Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	DrugBank PubMed	n/a	n/a	n/a	n/a	42	n/a	n/a	n/a	n/a
The University of Georgia Curated by ChEMBL					Assay Description In vitro antiviral activity against HIV-1 Reverse transcriptase wild type				Bioorg Med Chem Lett 13: 1993-6 (2003) BindingDB Entry DOI: 10.7270/Q2639Q86
The University of Georgia Curated by ChEMBL					More data for this Ligand-Target Pair
Serum albumin (Homo sapiens (Human))	BDBM50366817 (Epivir) Show SMILES Nc1ccn([C@@H]2CS[C@H](CO)O2)c(=O)n1 \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	n/a	0.440	n/a	n/a	n/a	n/a	n/a
Mercer University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to human serum albumin with excitation at 280 nm after 2 hrs by spectrofluorimetric analysis				Bioorg Med Chem Lett 25: 3168-71 (2015) BindingDB Entry DOI: 10.7270/Q21N82W0
Mercer University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50366817 (Epivir) Show SMILES Nc1ccn([C@@H]2CS[C@H](CO)O2)c(=O)n1 \|r\| Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	DrugBank PubMed	n/a	n/a	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a
The University of Georgia Curated by ChEMBL					Assay Description In vitro antiviral activity against HIV-1 Reverse transcriptase M184V mutant				Bioorg Med Chem Lett 13: 1993-6 (2003) BindingDB Entry DOI: 10.7270/Q2639Q86
The University of Georgia Curated by ChEMBL					More data for this Ligand-Target Pair
Multidrug resistance-associated protein 4 (Homo sapiens (Human))	BDBM50366817 (Epivir) Show SMILES Nc1ccn([C@@H]2CS[C@H](CO)O2)c(=O)n1 \|r\| Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	DrugBank PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...				Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Bile salt export pump (Homo sapiens (Human))	BDBM50366817 (Epivir) Show SMILES Nc1ccn([C@@H]2CS[C@H](CO)O2)c(=O)n1 \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...				Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Core antigen (Hepatitis B virus)	BDBM50366817 (Epivir) Show SMILES Nc1ccn([C@@H]2CS[C@H](CO)O2)c(=O)n1 \|r\| Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Xuzhou Medical University Curated by ChEMBL					Assay Description Inhibition of capsid protein in lamivudine/entecavir-resistant Hepatitis B virus harboring rtL180M/rtM204V/rt184L mutant infected in human HepG2.2.15...				Eur J Med Chem 176: 41-49 (2019) Article DOI: 10.1016/j.ejmech.2019.05.014
Xuzhou Medical University Curated by ChEMBL					More data for this Ligand-Target Pair
Canalicular multispecific organic anion transporter 2 (Homo sapiens (Human))	BDBM50366817 (Epivir) Show SMILES Nc1ccn([C@@H]2CS[C@H](CO)O2)c(=O)n1 \|r\| Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	DrugBank PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...				Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Core antigen (Hepatitis B virus)	BDBM50366817 (Epivir) Show SMILES Nc1ccn([C@@H]2CS[C@H](CO)O2)c(=O)n1 \|r\| Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Inhibition of capsid in HBV infected in human HepAD38 cells assessed as reduction in tetracycline-induced cccDNA formation by measuring reduction in ...				Eur J Med Chem 138: 407-421 (2017) Article DOI: 10.1016/j.ejmech.2017.06.062 BindingDB Entry DOI: 10.7270/Q2FT8PM9
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated L-type calcium channel (Homo sapiens (Human))	BDBM50366817 (Epivir) Show SMILES Nc1ccn([C@@H]2CS[C@H](CO)O2)c(=O)n1 \|r\| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	5.42E+4	n/a	n/a	n/a	n/a	n/a	n/a
ChanTest Corporation Curated by ChEMBL					Assay Description Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits				Sci Rep 3: (2013) Article DOI: 10.1038/srep02100 BindingDB Entry DOI: 10.7270/Q2RB77K2
ChanTest Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Core antigen (Hepatitis B virus)	BDBM50366817 (Epivir) Show SMILES Nc1ccn([C@@H]2CS[C@H](CO)O2)c(=O)n1 \|r\| Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Xuzhou Medical University Curated by ChEMBL					Assay Description Inhibition of capsid protein in Hepatitis B virus infected in human HepG2.2.15 cells assessed as reduction in viral DNA level at 4 uM supplemented wi...				Eur J Med Chem 176: 41-49 (2019) Article DOI: 10.1016/j.ejmech.2019.05.014
Xuzhou Medical University Curated by ChEMBL					More data for this Ligand-Target Pair
Canalicular multispecific organic anion transporter 1 (Homo sapiens (Human))	BDBM50366817 (Epivir) Show SMILES Nc1ccn([C@@H]2CS[C@H](CO)O2)c(=O)n1 \|r\| Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...				Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair