BDBM50006816 (LY-171883)1-{2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)-butoxy]-phenyl}-ethanone::1-{2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)-butoxy]-phenyl}-ethanone::1-{2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)-butoxy]-phenyl}-ethanone ( LY-171883)::1-{2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)-butoxy]-phenyl}-ethanone(LY 171,883)::1-{2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)-butoxy]-phenyl}-ethanone(LY-171883)::1-{2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)-butoxy]-phenyl}-ethanone(LY171883)::1-{2-Hydroxy-3-propyl-4-[4-(2H-tetrazol-5-yl)-butoxy]-phenyl}-ethanone::CHEMBL162358::LY-171883
SMILES: CCCc1c(OCCCCc2nnn[nH]2)ccc(C(C)=O)c1O
InChI Key: InChIKey=MWYHLEQJTQJHSS-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Cysteinyl leukotriene receptor 1 (GUINEA PIG) | BDBM50006816![]() ((LY-171883)1-{2-Hydroxy-3-propyl-4-[4-(1H-tetrazol...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Curated by ChEMBL | Assay Description The compound was tested for binding affinity against Cysteinyl leukotriene D4 receptor in guinea pig lung membrane | J Med Chem 35: 2501-24 (1992) BindingDB Entry DOI: 10.7270/Q23B60R4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cysteinyl leukotriene receptor 1 (GUINEA PIG) | BDBM50006816![]() ((LY-171883)1-{2-Hydroxy-3-propyl-4-[4-(1H-tetrazol...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
ICI Pharmaceuticals Group Curated by ChEMBL | Assay Description Compound was evaluated for its ability to displace [3H]-LTD4 from LTD4 receptor in guinea pig lung membranes | J Med Chem 34: 1235-42 (1991) BindingDB Entry DOI: 10.7270/Q2K936HB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cysteinyl leukotriene receptor (Homo sapiens (Human)) | BDBM50006816![]() ((LY-171883)1-{2-Hydroxy-3-propyl-4-[4-(1H-tetrazol...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rorer Central Research Curated by ChEMBL | Assay Description In vitro binding affinity against cysteinyl leukotriene D4 receptor from guinea pig lung membrane | J Med Chem 33: 2828-41 (1990) BindingDB Entry DOI: 10.7270/Q29C6WDM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cysteinyl leukotriene receptor 1 (GUINEA PIG) | BDBM50006816![]() ((LY-171883)1-{2-Hydroxy-3-propyl-4-[4-(1H-tetrazol...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 2.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
ICI Pharmaceuticals Group Curated by ChEMBL | Assay Description Displacement of [3H]-LTD4 on guinea pig lung parenchymal membranes | J Med Chem 33: 1781-90 (1990) BindingDB Entry DOI: 10.7270/Q2862FDP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclooxygenase (Homo sapiens (Human)) | BDBM50006816![]() ((LY-171883)1-{2-Hydroxy-3-propyl-4-[4-(1H-tetrazol...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 4.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Laboratories Curated by ChEMBL | Assay Description Ability to inhibit Prostaglandin G/H synthase in guinea pig | J Med Chem 30: 2087-93 (1987) BindingDB Entry DOI: 10.7270/Q2FQ9VMQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Arachidonate 5-lipoxygenase (Rattus norvegicus) | BDBM50006816![]() ((LY-171883)1-{2-Hydroxy-3-propyl-4-[4-(1H-tetrazol...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 4.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro for inhibition of LTB4 (leukotriene B4) production in isolated rat polymorphonuclear leukocytes (PMNs). | J Med Chem 29: 2329-34 (1986) BindingDB Entry DOI: 10.7270/Q2TH8KNT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclooxygenase (RAT) | BDBM50006816![]() ((LY-171883)1-{2-Hydroxy-3-propyl-4-[4-(1H-tetrazol...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 4.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Curated by ChEMBL | Assay Description Concentration for 50% inhibition of A-23187-stimulated radiolabeled 5-HETE and TXB2 synthesis by Prostaglandin G/H synthase | J Med Chem 33: 240-5 (1990) BindingDB Entry DOI: 10.7270/Q24Q7T0P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Arachidonate 5-lipoxygenase (Rattus norvegicus) | BDBM50006816![]() ((LY-171883)1-{2-Hydroxy-3-propyl-4-[4-(1H-tetrazol...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.89E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Ability to inhibit Lipoxygenase in vitro was determined | J Med Chem 30: 400-5 (1987) BindingDB Entry DOI: 10.7270/Q2K936JS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile salt export pump (Homo sapiens (Human)) | BDBM50006816![]() ((LY-171883)1-{2-Hydroxy-3-propyl-4-[4-(1H-tetrazol...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | <1.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-... | Drug Metab Dispos 40: 2332-41 (2012) Article DOI: 10.1124/dmd.112.047068 BindingDB Entry DOI: 10.7270/Q2ZP488M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Arachidonate 5-lipoxygenase (Rattus norvegicus) | BDBM50006816![]() ((LY-171883)1-{2-Hydroxy-3-propyl-4-[4-(1H-tetrazol...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 2.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro for inhibition of 5-HETE production in isolated rat polymorphonuclear leukocytes (PMNs) | J Med Chem 29: 2329-34 (1986) BindingDB Entry DOI: 10.7270/Q2TH8KNT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Arachidonate 5-lipoxygenase (Rattus norvegicus) | BDBM50006816![]() ((LY-171883)1-{2-Hydroxy-3-propyl-4-[4-(1H-tetrazol...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.89E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Curated by ChEMBL | Assay Description Concentration for 50% inhibition of A-23,187-stimulated radiolabelled 5-HETE and TXB2 synthesis by PMN 5-lipoxygenase | J Med Chem 33: 240-5 (1990) BindingDB Entry DOI: 10.7270/Q24Q7T0P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Arachidonate 5-lipoxygenase (Homo sapiens (Human)) | BDBM50006816![]() ((LY-171883)1-{2-Hydroxy-3-propyl-4-[4-(1H-tetrazol...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.89E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Laboratories Curated by ChEMBL | Assay Description Ability to inhibit 5-lipoxygenase in guinea pig | J Med Chem 30: 2087-93 (1987) BindingDB Entry DOI: 10.7270/Q2FQ9VMQ | |||||||||||
More data for this Ligand-Target Pair |