BindingDB PrimarySearch

BDBM50021365 CHEMBL407641::Mezilamine::[4-Chloro-6-(4-methyl-piperazin-1-yl)-5-methylsulfanyl-pyrimidin-2-yl]-methyl-amine

SMILES: CNc1nc(Cl)c(SC)c(n1)N1CCN(C)CC1

InChI Key: InChIKey=ITYXRJDDBZMFAY-UHFFFAOYSA-N

Data: 8 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50021365
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50021365 (CHEMBL407641 \| Mezilamine \| [4-Chloro-6-(4-methyl-...) Show SMILES CNc1nc(Cl)c(SC)c(n1)N1CCN(C)CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	5.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sumitomo Pharmaceuticals Curated by ChEMBL					Assay Description Binding affinity of the compound to Dopamine receptor D2 was determined				Bioorg Med Chem Lett 11: 1141-4 (2001) BindingDB Entry DOI: 10.7270/Q2QJ7GJ8
Sumitomo Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50021365 (CHEMBL407641 \| Mezilamine \| [4-Chloro-6-(4-methyl-...) Show SMILES CNc1nc(Cl)c(SC)c(n1)N1CCN(C)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro binding affinity was measured as the inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor of rat cortical membranes				J Med Chem 29: 1394-8 (1986) BindingDB Entry DOI: 10.7270/Q21R6SQQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50021365 (CHEMBL407641 \| Mezilamine \| [4-Chloro-6-(4-methyl-...) Show SMILES CNc1nc(Cl)c(SC)c(n1)N1CCN(C)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of [3H]idazoxan binding to alpha-2 adrenergic receptor of rat cortical membranes				J Med Chem 29: 1394-8 (1986) BindingDB Entry DOI: 10.7270/Q21R6SQQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)	BDBM50021365 (CHEMBL407641 \| Mezilamine \| [4-Chloro-6-(4-methyl-...) Show SMILES CNc1nc(Cl)c(SC)c(n1)N1CCN(C)CC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro ability to displace [3H]spiroperidol from rat dopamine receptor				J Med Chem 25: 1459-65 (1982) BindingDB Entry DOI: 10.7270/Q2SQ92KV
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)	BDBM50021365 (CHEMBL407641 \| Mezilamine \| [4-Chloro-6-(4-methyl-...) Show SMILES CNc1nc(Cl)c(SC)c(n1)N1CCN(C)CC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro binding affinity to Dopamine receptors of rat striatal membranes by [3H]spiroperidol displacement.				J Med Chem 29: 1394-8 (1986) BindingDB Entry DOI: 10.7270/Q21R6SQQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50021365 (CHEMBL407641 \| Mezilamine \| [4-Chloro-6-(4-methyl-...) Show SMILES CNc1nc(Cl)c(SC)c(n1)N1CCN(C)CC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	91	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro binding affinity was measured as the inhibition of [3H]WB-4101 binding to alpha-1 adrenergic receptor of rat cortical membranes				J Med Chem 29: 1394-8 (1986) BindingDB Entry DOI: 10.7270/Q21R6SQQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50021365 (CHEMBL407641 \| Mezilamine \| [4-Chloro-6-(4-methyl-...) Show SMILES CNc1nc(Cl)c(SC)c(n1)N1CCN(C)CC1 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	430	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sumitomo Pharmaceuticals Curated by ChEMBL					Assay Description Binding affinity of the compound to 5-hydroxytryptamine 1A receptor was determined				Bioorg Med Chem Lett 11: 1141-4 (2001) BindingDB Entry DOI: 10.7270/Q2QJ7GJ8
Sumitomo Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50021365 (CHEMBL407641 \| Mezilamine \| [4-Chloro-6-(4-methyl-...) Show SMILES CNc1nc(Cl)c(SC)c(n1)N1CCN(C)CC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sumitomo Pharmaceuticals Curated by ChEMBL					Assay Description Binding affinity of the compound to Dopamine receptor D4 was determined				Bioorg Med Chem Lett 11: 1141-4 (2001) BindingDB Entry DOI: 10.7270/Q2QJ7GJ8
Sumitomo Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair