BDBM50360468 CHEMBL4168375

SMILES: [H][C@@]12CC=C(c3ccc4cnncc4c3)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C

InChI Key: InChIKey=JDONUUHKKAFGNX-MVVRIGEBSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50360468   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50360468 (CHEMBL4168375) Show SMILES [H][C@@]12CC=C(c3ccc4cnncc4c3)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C |r,t:3,28| Show InChI InChI=1S/C27H32N2O/c1-26-11-9-21(30)14-20(26)5-6-22-24-8-7-23(27(24,2)12-10-25(22)26)17-3-4-18-15-28-29-16-19(18)13-17/h3-5,7,13,15-16,21-22,24-25,30H,6,8-12,14H2,1-2H3/t21-,22-,24-,25-,26-,27+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dana-Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of CDK8 (unknown origin)				ACS Med Chem Lett 9: 540-545 (2018) Article DOI: 10.1021/acsmedchemlett.8b00011 BindingDB Entry DOI: 10.7270/Q2125W6Z
					More data for this Ligand-Target Pair