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BDBM50484632 MK-6186::MK6186::Mk-6186::Mk6186

SMILES: Clc1cc(Oc2c(Cl)ccc3n(Cc4n[nH]c5ncccc45)ncc23)cc(c1)C#N

InChI Key: InChIKey=FZBAOOQVQXATRL-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50484632   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Reverse Transcriptase


(Human immunodeficiency virus 1)		BDBM50484632
PNG
(MK-6186 | MK6186 | Mk-6186 | Mk6186)
Show SMILES Clc1cc(Oc2c(Cl)ccc3n(Cc4n[nH]c5ncccc45)ncc23)cc(c1)C#N
Show InChI InChI=1S/C21H12Cl2N6O/c22-13-6-12(9-24)7-14(8-13)30-20-16-10-26-29(19(16)4-3-17(20)23)11-18-15-2-1-5-25-21(15)28-27-18/h1-8,10H,11H2,(H,25,27,28)
PDB
MMDB

UniProtKB/TrEMBL

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PC cid
PC sid
UniChem
Article
PubMed
 0.580n/an/an/an/an/an/an/an/a



Merck Co.

Curated by ChEMBL


Assay Description
Inhibition of Human immunodeficiency virus reverse transcriptase K103N mutant by SPA assay

J Med Chem 54: 7920-33 (2011)


Article DOI: 10.1021/jm2010173
BindingDB Entry DOI: 10.7270/Q2W66PMC
More data for this
Ligand-Target Pair