BDBM50230001 4-(4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl)pyridine::4-(4-fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole::4-[5-(4-Fluoro-phenyl)-2-(4-nitro-phenyl)-3H-imidazol-4-yl]-pyridine::CHEMBL17331::PD-169316
SMILES: [O-][N+](=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
InChI Key: InChIKey=BGIYKDUASORTBB-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Arachidonate 5-lipoxygenase (Rattus norvegicus) | BDBM50230001 (4-(4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazo...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against 5-lipoxygenase enzyme from RBL-1 cells | Bioorg Med Chem Lett 5: 1171-1176 (1995) Article DOI: 10.1016/0960-894X(95)00189-Z BindingDB Entry DOI: 10.7270/Q28S4PV1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Arachidonate 5-lipoxygenase (Homo sapiens (Human)) | BDBM50230001 (4-(4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytes | Bioorg Med Chem Lett 5: 1171-1176 (1995) Article DOI: 10.1016/0960-894X(95)00189-Z BindingDB Entry DOI: 10.7270/Q28S4PV1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
p38 MAP kinase alpha/beta (Homo sapiens (Human)) | BDBM50230001 (4-(4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosinase (Mus musculus (Mouse)) | BDBM50230001 (4-(4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazo...) | UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn Curated by ChEMBL | Assay Description Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction in melanin synthesis after 2 hrs by spectrophotometric analysis | J Med Chem 61: 7395-7418 (2018) Article DOI: 10.1021/acs.jmedchem.7b00967 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosinase (Mus musculus (Mouse)) | BDBM50230001 (4-(4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazo...) | UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn Curated by ChEMBL | Assay Description Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction in melanin synthesis after 2 hrs by spectrophotometric analysis | J Med Chem 61: 7395-7418 (2018) Article DOI: 10.1021/acs.jmedchem.7b00967 | |||||||||||
More data for this Ligand-Target Pair |